Gene therapy injection aims to cure radiation dry mouth
NCT ID NCT06714253
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a new treatment called RXRG001 for people with long-term dry mouth and low saliva after radiation therapy for cancer. The treatment is a genetic material delivered directly into the saliva glands to help them produce more fluid. The study involves 42 adults and will first check safety, then see if it improves saliva production.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RXRG001 (a genetic material that instructs cells to produce a protein to help saliva flow)
- What this could lead to
- If it works, this could lead to a treatment that restores saliva production and relieves chronic dry mouth in people who have had radiation for head and neck cancer.
- What could go wrong
- This is a very early, first-in-human trial with only 42 participants. The treatment is injected directly into the saliva gland, which carries risks like infection or swelling. It may not work or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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John Hopkins University, Sidney Kimmel Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact
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NYU Langone Medical Center
RECRUITINGNew York, New York, 10016-6402, United States
Contact
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Penn Medicine - Otorhinolaryngology - Head and Neck Surgery Perelman
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
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University of Iowa Hospitals and Clinics
RECRUITINGIowa City, Iowa, 52242, United States
Contact