Can stem cells save sight? new trial tests eye cell transplant for dry AMD
NCT ID NCT04627428
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether transplanting lab-grown retinal cells (RPESC-RPE-4W) into the eye is safe for people with dry age-related macular degeneration (AMD), a leading cause of vision loss. About 18 adults over 55 will receive the transplant and be monitored for side effects like vision decline, inflammation, or tumor growth. The goal is to see if the procedure is safe enough to study further as a potential treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RPESC-RPE-4W (retinal pigment epithelium stem cell-derived cells)
What this could lead to
If successful, this could point toward a cell-based treatment to slow or stop vision loss in dry AMD.
What could go wrong
This is an early-phase trial with only 18 participants, so results may not apply broadly. Risks include vision loss, inflammation, or tumor formation.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Retina Vitreous Associates Medical Group
RECRUITINGBeverly Hills, California, 90211, United States
Contact
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Spencer Center for Vision Research
RECRUITINGPalo Alto, California, 94303, United States
Contact
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University of Michigan Kellogg Eye Center
RECRUITINGAnn Arbor, Michigan, 48105, United States
Contact