New hope for advanced bowel cancer: experimental drug combo enters major trial

NCT ID NCT07221357

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tests whether a new drug called pumitamig, when added to chemotherapy, works better than the current standard treatment (bevacizumab plus chemo) for people with advanced colorectal cancer that cannot be removed by surgery. About 990 adults who have not had prior treatment for their metastatic disease will take part. The goal is to see if the new combination shrinks tumors, delays cancer growth, and helps people live longer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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ASST Grande Ospedale Metropolitano Niguarda
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Milan, Milano, 20162, Italy

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Roeselare, West-Vlaanderen, 8800, Belgium

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Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
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Azienda Ospedaliero Universitaria Pisana
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CHU Rangueil
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Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
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Craiova, Dolj, 200542, Romania

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Chang Gung Medical Foundation-Linkou Branch
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Facharztzentrum Eppendorf
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Fundeni Clinical Institute
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GenesisCare St Leonards
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H.R.U Málaga - Hospital General
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Hokkaido University Hospital
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Hospital General Universitario Gregorio Marañon
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Hospital Universitario Virgen Del Rocio
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Seville, 41013, Spain

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Hôpital Saint Antoine
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Paris, 75571, France

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IRCCS Casa Sollievo della Sofferenza
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San Giovanni Rotondo, Foggia, 71013, Italy

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Instituto Alexander Fleming
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

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Institutul Oncologic Cluj
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Cluj-Napoca, 400015, Romania

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Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
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Cluj-Napoca, Cluj, 400162, Romania

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Institutul Regional de Oncologie
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Iași, 700483, Romania

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Istituto Nazionale Tumori IRCCS Fondazione Pascale
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Naples, 80131, Italy

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Istituto Oncologico Veneto IRCCS
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Padova, Veneto, 35128, Italy

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Jewish General Hospital
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Montreal, Quebec, H3T 1E2, Canada

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Kaohsiung Medical University Chung-Ho Memorial Hospital
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Kaohsiung City, 807, Taiwan

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Klinikum Neuperlach
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München, 81737, Germany

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Krankenhaus Der Barmherzigen Schwestern Linz
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Linz, 4010, Austria

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Krankenhaus Nordwest GmbH
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Frankfurt, 60488, Germany

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Lehigh Valley Health Network
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Allentown, Pennsylvania, 18103, United States

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Delhi, 110029, India

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Nashik, Dādra and Nagar Haveli and Damān and Diu, 422001, India

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Berlin, 10117, Germany

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Mannheim, 68167, Germany

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Mainz, 55131, Germany

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Bochum, 44791, Germany

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Ankara, 06100, Turkey (Türkiye)

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Stockholm, Stockholm County, 17176, Sweden

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Vienna, A-1090, Austria

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Villejuif, 94805, France

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Edegem, Antwerpen, 2650, Belgium

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Milan, 20133, Italy

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Amsterdam, North Holland, 1105 AZ, Netherlands

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Brussels, 1000, Belgium

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Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France

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Nantes, Pays de la Loire Region, 44093, France

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Guangzhou, Guangdong, 510555, China

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Floresti/ Cluj, 407280, Romania

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Singapore, 119074, Singapore

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Adelaide, South Australia, 5042, Australia

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Wentworthville, NSW2145, Australia

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Malvern, 3144, Australia

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Badalona, Barcelona [Barcelona], 08916, Spain

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Feldkirch, 6800, Austria

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Utrecht, 3543 AZ, Netherlands

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Groningen, 9713 GZ, Netherlands

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Recoleta, Santiago Metropolitan, 8420391, Chile

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Eindhoven, North Brabant, 5623 EJ, Netherlands

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Buenos Aires, 1039, Argentina

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Sankt Pölten, 3100, Austria

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Brno, 656 53, Czechia

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Saint-Herblain, Loire-Atlantique, 44805, France

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Gothenburg, Västra Götaland County, 41685, Sweden

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Hradec Králové, 500 05, Czechia

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Epping, Victoria, 3076, Australia

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Woolloongabba, Queensland, 4102, Australia

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Veszprém, 8200, Hungary

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Tilburg, 5022 GC, Netherlands

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Catania, 95124, Italy

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Madrid, Madrid, Comunidad de, 28041, Spain

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Reggio Emilia, 42123, Italy

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Barcelona, Barcelona [Barcelona], 08035, Spain

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Prague, Praha 5, 150 06, Czechia

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Houston, Texas, 77030, United States

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Seattle, Washington, 98109, United States

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Grand Rapids, Michigan, 49546, United States

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Ottawa, Ontario, K1H 8L6, Canada

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Baltimore, Maryland, 21287, United States

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São José do Rio Preto, 15090-000, Brazil

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Barretos, São Paulo, 14784400, Brazil

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Curitiba, Paraná, 81480-580, Brazil

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São Paulo, 01246-000, Brazil

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Mineola, New York, 11501, United States

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New Hyde Park, New York, 11042, United States

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Atlanta, Georgia, 30342, United States

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Liverpool, New South Wales, 2170, Australia

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Singapore, 308442, Singapore

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Charlotte, North Carolina, 28207, United States

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Stanford, California, 94305, United States

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Kadiköy/Istanbul, 41380, Turkey (Türkiye)

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Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan

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Glasgow, G12 0YN, United Kingdom

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Newcastle upon Tyne, NE7 7DN, United Kingdom

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San Francisco, California, 94115, United States

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Kansas City, Missouri, 64111, United States

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Santa Monica, California, 90404, United States

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Natal/RN, Rio Grande do Norte, 59062-000, Brazil

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Nashville, Tennessee, 37203, United States

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Omaha, Nebraska, 68198, United States

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Iowa City, Iowa, 52242, United States

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Columbus, Ohio, 43210, United States

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São Paulo, 01308-060, Brazil

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Porto Alegre, Rio Grande do Sul, 91610-000, Brazil

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Shenyang, Liaoning, 110001, China

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Harbin, Heilongjiang, 150081, China

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Fuzhou, Fujian, 350014, China

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Shenyang, Liaoning, 110042, China

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Shanghai, 200032, China

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Warsaw, Masovian Voivodeship, 03-411, Poland

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Hangzhou, Zhejiang, 310003, China

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Koszalin, West Pomeranian Voivodeship, 75-581, Poland

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Opole, 45-372, Poland

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Krakow, Lesser Poland Voivodeship, 31-826, Poland

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Brzozów, Podkarpackie Voivodeship, 36-200, Poland

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Oxford, Oxfordshire, OX3 7LJ, United Kingdom

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Santa Cruz do Sul, Rio Grande do Sul, 96810-110, Brazil

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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

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Changsha, Hunan, 410013, China

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Shanghai, Shanghai Municipality, 200120, China

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Nanchang, Jiangxi, 330006, China

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Jinan, Shandong, 250117, China

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Hangzhou, Zhejiang, 310022, China

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Nanyang, Henan, 473009, China

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Fuzhou Fujian, Fujian, 350001, China

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Tianjin, Hebei, 300060, China

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Wuhan, Hubei, 430079, China

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Yangzhou, Jiangsu, 225001, China

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Lund, 22184, Sweden

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Seoul, 120-752, South Korea

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Beijing, 100034, China

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Changsha, Hunan, 410031, China

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Wuhan, 430022, China

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Guangzhou, Guangdong, 510000, China

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Nanjing, Jiangsu, 210009, China

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Toronto, Ontario, M5G 2M9, Canada

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Toronto, Ontario, M4N 3M5, Canada

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Salt Lake City, Utah, 84102, United States

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Ann Arbor, Michigan, 48109, United States

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Springdale, Arkansas, 72762, United States

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Chicago, Illinois, 60637, United States

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Chapecó, Santa Catarina, 89812-211, Brazil

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La Jolla, California, 92037, United States

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Gliwice, Silesian Voivodeship, 44-101, Poland

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Jelenia Góra, Lower Silesian Voivodeship, 58-506, Poland

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Hangzhou, 310009, China

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Prague, Praha, Hlavní Mesto, 12808, Czechia

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Santiago, Santiago Metropolitan, 7500921, Chile

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Olomouc, 77520, Czechia

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Boston, Massachusetts, 02114, United States
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Elche (alicante), 03203, Spain

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Chikusa-ku, 464-8681, Japan

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Kurashiki, Okayama-ken, 710-8602, Japan

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Prague, Praha 10, 10034, Czechia

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Edmonds, Washington, 98026-8032, United States

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Chengdu, Sichuan, 610041, China

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Chongqing, Chongqing Municipality, 400030, China

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Osaka, 541-8567, Japan

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Singapore, 329563, Singapore

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St Albans, Victoria, 3021, Australia

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Takatsuki, Osaka, 569-8686, Japan

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Warsaw, Masovian Voivodeship, 02-507, Poland

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Fargo, North Dakota, 58102, United States

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Birmingham, West Midlands, B15 2TT, United Kingdom

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Calgary, Alberta, T2N 5G2, Canada

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Mumbai, Maharashtra, 400036, India
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Delhi, 110029, India

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Puducherry, 605006, India
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Chemnitz, 09113, Germany

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Besançon, Doubs, 25000, France

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Erlangen, Bavaria, 91054, Germany

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Santiago de Compostela, 15706, Spain

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Hamburg, 22763, Germany

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Hefei, Anhui, 230601, China

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Kitaadachi-gun, 362-0806, Japan

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Enfield, London, EN28JL, United Kingdom

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Cardiff, CF14 2TL, United Kingdom

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Dorchester, DT1 2JY, United Kingdom

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Pittsburgh, Pennsylvania, 15232, United States

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Local Institution - 0605
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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Local Institution - 0607
NOT_YET_RECRUITING

Hanover, Lower Saxony, 30161, Germany

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Local Institution - 0609
NOT_YET_RECRUITING

Avellino, 83100, Italy

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Local Institution - 0610
NOT_YET_RECRUITING

Bari, 70124, Italy

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Local Institution - 0612
NOT_YET_RECRUITING

Ravenna, 48121, Italy

Contact
Local Institution - 0613
NOT_YET_RECRUITING

Lille, Nord, 59020, France

Contact
Local Institution - 0614
NOT_YET_RECRUITING

Aviano, Pordenone, 33081, Italy

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Local Institution - 0615
NOT_YET_RECRUITING

La Spezia, 19124, Italy

Contact
Local Institution - 0616
NOT_YET_RECRUITING

Limoges, 87042, France

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Local Institution - 0617
NOT_YET_RECRUITING

Castellana Grotte, Bari, 70013, Italy

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Local Institution - 0618
NOT_YET_RECRUITING

Lorient, Morbihan, 56100, France

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Local Institution - 0619
NOT_YET_RECRUITING

Tricase, Lecce, 73039, Italy

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Local Institution - 0620
WITHDRAWN

Charleroi, Hainaut, 6060, Belgium
Local Institution - 0622
NOT_YET_RECRUITING

Bonheiden, Antwerpen, 2820, Belgium

Contact
Local Institution - 0624
NOT_YET_RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain

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Local Institution - 0625
NOT_YET_RECRUITING

Salamanca, 37007, Spain

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Local Institution - 0626
NOT_YET_RECRUITING

Gdansk, Pomeranian Voivodeship, 80-219, Poland

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Local Institution - 0629
NOT_YET_RECRUITING

Spokane, Washington, 99218, United States

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Local Institution - 0630
NOT_YET_RECRUITING

Córdoba, X5000JHQ, Argentina

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Local Institution - 0632
NOT_YET_RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina

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Local Institution - 0634
NOT_YET_RECRUITING

Suresnes, 92151, France

Contact
Local Institution - 0638
NOT_YET_RECRUITING

Fort Wayne, Indiana, 46805, United States

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Local Institution - 0641
NOT_YET_RECRUITING

Toyoake, Aichi-ken, 470-1192, Japan

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Local Institution - 0642
NOT_YET_RECRUITING

Yamagata, Yamagata, 990-9585, Japan

Contact
Local Institution - 0643
NOT_YET_RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact
Luxmed Onkologia sp. z o. o.
RECRUITING

Warsaw, Masovian Voivodeship, 01-748, Poland

Contact Phone: •••-•••-••••
Lyell McEwin Hospital
RECRUITING

Elizabeth Vale, South Australia, 5112, Australia

Contact Phone: •••-•••-••••
Maidstone and Tunbridge Wells NHS Trust
RECRUITING

Maidstone, ME16 9QQ, United Kingdom

Contact Phone: •••-•••-••••
Marien Hospital Düsseldorf
RECRUITING

Düsseldorf, 40479, Germany

Contact Phone: •••-•••-••••
Maryland Oncology Hematology - Silver Spring
RECRUITING

Silver Spring, Maryland, 20904, United States

Contact
Minnesota Oncology
RECRUITING

Maple Grove, Minnesota, 55369, United States

Contact
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-••••
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan

Contact Phone: •••-•••-••••
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan

Contact Phone: •••-•••-••••
National Cancer Centre Singapore
RECRUITING

Singapore, Central Singapore, 168583, Singapore

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan

Contact Phone: •••-•••-••••
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan

Contact Phone: •••-•••-••••
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan

Contact Phone: •••-•••-••••
Northwell Health/ RJ Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States

Contact Phone: •••-•••-••••
Northwest Cancer Specialists, P.C.
RECRUITING

Vancouver, Washington, 98684, United States

Contact Phone: •••-•••-••••
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
RECRUITING

Marietta, Georgia, 30060, United States

Contact Phone: •••-•••-••••
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy

Contact Phone: •••-•••-••••
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, Queensland, 4029, Australia

Contact Phone: •••-•••-••••
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom

Contact Phone: •••-•••-••••
Royal Marsden Hospital Sutton
RECRUITING

London, SM2 5PT, United Kingdom

Contact Phone: •••-•••-••••
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania

Contact Phone: •••-•••-••••
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-••••
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

Contact Phone: •••-•••-••••
Sanford Cancer Center
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Phone: •••-•••-••••
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Gyeonggido, 13620, South Korea

Contact Phone: •••-•••-••••
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

Contact Phone: •••-•••-••••
St. John of God Murdoch Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia

Contact Phone: •••-•••-••••
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia

Contact Phone: •••-•••-••••
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States

Contact Phone: •••-•••-••••
Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North
RECRUITING

Arlington, Texas, 76012, United States

Contact
Texas Oncology, PA
RECRUITING

Austin, Texas, 78705, United States

Contact Phone: •••-•••-••••
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan

Contact Phone: •••-•••-••••
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06591, South Korea

Contact Phone: •••-•••-••••
The Christie NHS Foundation Trust
RECRUITING

Manchester, Lancashire, M20 4BX, United Kingdom

Contact
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan

Contact Phone: •••-•••-••••
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Phone: •••-•••-••••
UZ Leuven
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium

Contact Phone: •••-•••-••••
Universitaetsklinik Salzburg
RECRUITING

Salzburg, 5020, Austria

Contact Phone: •••-•••-••••
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, Saxony, 01307, Germany

Contact Phone: •••-•••-••••
Universitaetsmedizin Goettingen
RECRUITING

Göttingen, 37075, Germany

Contact Phone: •••-•••-••••
Universitatsklinikum Leipzig
RECRUITING

Leipzig, D-04103, Germany

Contact
University of California, Irvine (UCI) Health - UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States

Contact Phone: •••-•••-••••
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

Contact Phone: •••-•••-••••
Washington University School OF Medicine-Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

UNTREATED, UNRESECTABLE, OR METASTATIC COLORECTAL CANCER