Lung imaging could reveal the best anesthetic dose for breast surgery

NCT ID NCT07079436

Knowledge-focused Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers at Fudan University are studying how three strengths of the local anesthetic ropivacaine affect lung ventilation when used for intercostal nerve blocks during breast quadrantectomy. The trial enrolls 67 adults scheduled for this surgery and randomly assigns them to receive 0.25%, 0.375%, or 0.5% ropivacaine. A non-invasive imaging method called electrical impedance tomography monitors lung airflow before and after the block. The goal is to find which strength best balances pain relief with safety for breathing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: ropivacaine, a local anesthetic given as an intercostal nerve block
What this could lead to: If the trial succeeds, it could help doctors pick a ropivacaine strength that controls pain while preserving lung function for same-day breast surgery.
What could go wrong: This is a small, single-center study of 67 adults, so the results may not apply to other patients or hospitals. Ropivacaine can rarely cause allergic reactions, low blood pressure, or temporary breathing changes.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

67 people

The number who actually took part.

Started

Jul 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for elective breast quadrantectomy; * Aged 18-80 years; * American Society of Anesthesiologists (ASA) physical status I-II; * Body mass index (BMI) \<35 kg/m². Exclusion Criteria: * Contraindications for nerve block: infection at the puncture site, local anesthetic allergy, coagulation dysfunction or bleeding risk; * Patients with unilateral diaphragmatic paralysis; * Patients with severe ventilatory or gas exchange dysfunction; * Complicated with acute or chronic pulmonary and bronchial diseases, sleep apnea syndrome; * Mental disorders; * Patients who refuse to participate; * Patients whom the researchers consider unsuitable for the clinical trial, with reasons to be specified.

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Conditions

The condition(s) this trial relates to.

breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia, local Breast neoplasms Intercostal nerve block Pulmonary ventilation Surgical procedures, operative

Lung imaging could reveal the best anesthetic dose for breast surgery

What the study statuses mean