Double-Targeting CAR t therapy aims to outperform standard treatment in lymphoma
NCT ID NCT07188558
First seen Sep 30, 2025 · Last updated May 15, 2026 · Updated 30 times
Summary
This study tests a new cell therapy called ronde-cel that targets two proteins (CD19 and CD20) on lymphoma cells, compared to standard CAR T-cell therapy that targets only one. About 400 adults with large B-cell lymphoma that came back or didn't respond to first treatment will take part. The goal is to see if the dual-targeting approach helps keep the cancer away longer.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AdventHealth
NOT_YET_RECRUITINGOrlando, Florida, 32804, United States
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Allegheny Health Network
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Atrium Health Wake Forest Baptist Comprehensive Cancer Center
NOT_YET_RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Banner MD Anderson Cancer Center
NOT_YET_RECRUITINGGilbert, Arizona, 85234, United States
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Cedars-Sinai Medical Center
NOT_YET_RECRUITINGLos Angeles, California, 90048, United States
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Cleveland Clinical Taussig Cancer Center
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
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Colorado Blood Cancer Institute
RECRUITINGDenver, Colorado, 80218, United States
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Corewell Health
NOT_YET_RECRUITINGGrand Rapids, Michigan, 49503, United States
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Duke Cancer Institute
NOT_YET_RECRUITINGDurham, North Carolina, 27705, United States
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Hackensack
NOT_YET_RECRUITINGHackensack, New Jersey, 07601, United States
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Honor Health
NOT_YET_RECRUITINGScottsdale, Arizona, 85258, United States
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Intermountain Healthcare
RECRUITINGSalt Lake City, Utah, 84143, United States
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MD Anderson Cancer Center
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic Arizona
NOT_YET_RECRUITINGScottsdale, Arizona, 85259, United States
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Mayo Clinic Florida
NOT_YET_RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Rochester
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
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MedStar Georgetown University Hospital
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Moffitt Cancer Center
NOT_YET_RECRUITINGTampa, Florida, 33612, United States
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Northside Hospital
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30342, United States
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Northwestern
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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Oncology Hematology Care Clinical Trials
NOT_YET_RECRUITINGCincinnati, Ohio, 45242, United States
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Roswell Park Comprehensive Cancer Center
NOT_YET_RECRUITINGBuffalo, New York, 14263, United States
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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St. David's South Austin Medical Center
RECRUITINGAustin, Texas, 78704, United States
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Swedish Cancer Institute
NOT_YET_RECRUITINGSeattle, Washington, 98104, United States
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Texas Transplant Institute
RECRUITINGSan Antonio, Texas, 78229, United States
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University of Arkansas
NOT_YET_RECRUITINGLittle Rock, Arkansas, 72205, United States
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University of California, Irvine
NOT_YET_RECRUITINGOrange, California, 92868, United States
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University of California, Los Angeles (UCLA)
NOT_YET_RECRUITINGLos Angeles, California, 90095, United States
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University of Chicago
NOT_YET_RECRUITINGChicago, Illinois, 60637, United States
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University of Cincinnati
NOT_YET_RECRUITINGCincinnati, Ohio, 45267, United States
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University of Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
NOT_YET_RECRUITINGIowa City, Iowa, 52242, United States
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University of Kansas Cancer Center
NOT_YET_RECRUITINGWestwood, Kansas, 66205, United States
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University of Kentucky
NOT_YET_RECRUITINGLexington, Kentucky, 40536, United States
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University of Louisville Health
NOT_YET_RECRUITINGLouisville, Kentucky, 40202, United States
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University of Nebraska Medical Center (UNMC)
NOT_YET_RECRUITINGOmaha, Nebraska, 68105, United States
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University of Texas Southwestern Medical Center
NOT_YET_RECRUITINGFort Worth, Texas, 76104, United States
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Virginia Oncology Associates
RECRUITINGNorfolk, Virginia, 23502, United States
Conditions
Explore the condition pages connected to this study.