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Could stress be the key to rosacea?

NCT ID NCT03989492

Knowledge-focused Sponsor: Kristen Metzler-Wilson Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This completed study looked at how the sympathetic nervous system (the 'fight or flight' response) might be involved in rosacea, a skin condition causing facial redness. Researchers measured nerve activity and skin blood flow in 40 people with and without rosacea during mental math, exercise, and local heating. The goal was to better understand triggers to help develop improved treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this research succeeds, it could point toward new treatments for rosacea that target the nervous system.
What could go wrong
This is a small, early-stage observational study, not a treatment trial. It may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

May 2019

Finished

Aug 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects. Exclusion Criteria: * Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders * Current history of alcohol and/or drug abuse * Known allergies or hypersensitivities to medications/drugs that are used in the protocol * Current smoking or regular smoking within the last 2 years * Body mass index \> 35 kg/m2 * Medications or supplements which are known to affect neural, cardiovascular, or muscular responses

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Conditions

The condition(s) this trial relates to.

rosacea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rosacea

Contacts and locations

Locations

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • University of Kentucky

    Lexington, Kentucky, 40506, United States

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