New mRNA vaccine aims to stop colorectal cancer recurrence in High-Risk patients

NCT ID NCT04486378

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 27 times

Summary

This phase 2 trial tests an experimental mRNA vaccine (RO7198457) in 327 people with stage II or III colorectal cancer who had surgery but still have cancer DNA in their blood. The vaccine is designed to train the immune system to attack remaining cancer cells. Participants are randomly assigned to receive the vaccine or be watched closely. The goal is to see if the vaccine can prevent the cancer from returning.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AZ Delta Roeselare

    Roeselare, 8800, Belgium

  • AZ Groeninge

    Kortrijk, 8500, Belgium

  • Allina Health

    Minneapolis, Minnesota, 55407, United States

  • Asklepios Klinik Altona

    Hamburg, 22763, Germany

  • Beatson West of Scotland Cancer Centre - Gartnavel Royal Hospital - NHS Greater Glasgow and Clyde

    Glasgow, G12 0XH, United Kingdom

  • Centres Hospitaliers Jolimont

    La Louvière, 7100, Belgium

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Churchill Hospital - Oxford University Hospitals NHS Foundation Trust

    Oxford, OX3 7LE, United Kingdom

  • Clinica Universitaria de Navarra

    Pamplona, 31008, Spain

  • Complejo Hospitalario Universitario A Coruna

    A Coruña, 15006, Spain

  • Complejo Hospitalario Universitario De Santiago De Compostela

    Santiago de Compostela, 15706, Spain

  • Complejo Hospitalario de Navarra (CHN)

    Pamplona, 31008, Spain

  • Complejo Hospitalario de Orense

    Ourense, 32005, Spain

  • Complexo Hospitalario Universitario de Vigo (CHUVI)

    Vigo, 36312, Spain

  • Consorcio Hospital General Valencia

    Valencia, 46014, Spain

  • Dorset County Hospital NHS Foundation Trust - Dorset County Hospital

    Dorchester, DT1 2JY, United Kingdom

  • GHDC (Grand Hopital de Charleroi)

    Charleroi, 6000, Belgium

  • GasthuisZusters Antwerpen - Sint-Augustinus

    Wilrijk, 2610, Belgium

  • Guy's and St Thomas' Hospital NHS Foundation Trust

    London, SE1 7EH, United Kingdom

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007, Spain

  • Hospital Nuestra Senora de Sonsoles

    Ávila, 05004, Spain

  • Hospital Regional Universitario Carlos Haya Malaga - Instituto de Investigacion Biomedica de Malaga

    Málaga, 29011, Spain

  • Hospital Universitari Germans Trias - ICO Badalona

    Badalona, 08916, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario HMN Sanchinarro, Centro Integral Oncologico Clara Campal (CIOCC)

    Madrid, 28050, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Marques De Valdecilla

    Santander, 39008, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Puerta de Hierro de Majadahonda

    Majadahonda, 28222, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario Virgen del Rocio - Hospital de la Mujer

    Seville, 41013, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 8041, Spain

  • Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital

    Cottingham, HU16 5JQ, United Kingdom

  • Hämatologisch-Onkologische Praxis Eppendorf

    Hamburg, 20249, Germany

  • Imeldaziekenhuis General Hospital

    Bonheiden, 2820, Belgium

  • Indiana University Melvin and Bren Simon Comprehensive Cancer

    Indianapolis, Indiana, 46202, United States

  • Institut Clinic Hematolo/Oncologia- ICMHO, Hospital Clinic i Provincial de Barcelona

    Barcelona, 8036, Spain

  • John Muir Clinical Research Center

    Concord, California, 94520, United States

  • Klinikum der Philipps-Universität Marburg

    Marburg, 35043, Germany

  • Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF)

    Frankfurt am Main, 60488, Germany

  • LMU Klinikum (Campus Großhadern) Medizinische Klinik Universität München

    München, 81377, Germany

  • Lunds Universitet - Medicinska Fakulteten (Lund University Faculty of Medicine)

    Lund, 221 00, Sweden

  • Marin Cancer Care

    Greenbrae, California, 94904, United States

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • National Center for Tumor Diseases (NCT) Heidelberg

    Heidelberg, 69120, Germany

  • Northwest Cancer Specialists P.C.

    Vancouver, Washington, 98684, United States

  • OhO Ostholstein Onkologie

    Oldenburg in Holstein, 23758, Germany

  • Oncology Hematology Care Clinical Trials

    Cincinnati, Ohio, 45245, United States

  • Princess Margaret Cancer Centre

    Toronto, M5G 1X6, Canada

  • Prosper Hospital

    Recklinghausen, 45659, Germany

  • Queen Elizabeth Hospital Birmingham-University Hospitals Birmingham NHS Foundation Trust

    Birmingham, B15 2GW, United Kingdom

  • Rhode Island Hospital

    Providence, Rhode Island, 02906, United States

  • Rocky Mountain Cancer Centers - Denver Midtwon

    Denver, Colorado, 80218, United States

  • Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust

    Preston, PR2 9HT, United Kingdom

  • SLK-Kliniken Heilbronn GmbH

    Heilbronn, 74078, Germany

  • Sarah Cannon (Tennessee Oncology - Nashville)

    Nashville, Tennessee, 37203, United States

  • Sodersjukhuset, Onkologiska Kliniken

    Stockholm, 11883, Sweden

  • St Bartholomew's Hospital-Barts Health NHS Trust

    London, EC1A 7BE, United Kingdom

  • Studiengesellschaft BSF

    Halle, 06108, Germany

  • Städtisches Klinikum München GmbH, Klinikum Neuperlach

    München, 81737, Germany

  • Texas Oncology - Northeast Texas

    Tyler, Texas, 75702, United States

  • Texas Oncology, P.A. - Austin

    Austin, Texas, 78705, United States

  • Texas Oncology-Baylor Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Texas Oncology-San Antonio Medical Center

    San Antonio, Texas, 78240, United States

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • The Clatterbridge Cancer Centre NHS Foundation Trust

    Bebington, CH63 4JY, United Kingdom

  • The Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • The Ottawa Hospital Cancer Centre

    Ottawa, K1H 8M2, Canada

  • The Royal Marsden NHS Foundation Trust

    Sutton, SM25NG, United Kingdom

  • The Royal Marsden NHS Foundation Trust- Chelsea

    London, SW3 6JJ, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Torbay Hospital - South Devon Healthcare Nhs Foundation Trust, Lowes Bridge

    Torquay, TQ2 7AA, United Kingdom

  • Universitaetsklinikum Leipzig AoeR

    Leipzig, 04103, Germany

  • Universitaetsklinikum St. Josef-Hospital Bochum

    Bochum, 44791, Germany

  • Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz KoeR

    Mainz, 55131, Germany

  • Universitaire Ziekenhuizen Leuven

    Leuven, 3000, Belgium

  • Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc

    Woluwe-Saint-Lambert, 1200, Belgium

  • University College London Hospitals NHS Foundation Trust

    London, NW2 1PG, United Kingdom

  • University of Washington

    Seattle, Washington, 98109, United States

  • University of Wisconsin Carbone Cancer Center

    Madison, Wisconsin, 53792, United States

  • Universitätsklinikum Bonn, Med. Klinik u. Poliklinik I

    Bonn, 53105, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Universitätsklinikum Würzburg

    Würzburg, 97080, Germany

  • VZW Algemeen Ziekenhuis AZ Klina

    Brasschaat, 2930, Belgium

  • Velindre NHS Trust, Velindre Cancer Centre

    Cardiff, CF14 2TL, United Kingdom

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.