New hope for rare gut cancer: drug showdown after standard therapy fails

NCT ID NCT04633122

First seen Apr 06, 2026 · Last updated May 12, 2026 · Updated 5 times

Summary

This study tested a new drug called ripretinib against an older drug, sunitinib, in 108 people with advanced gastrointestinal stromal tumors (GIST) whose cancer had stopped responding to the first-line treatment imatinib. The goal was to see which drug better delays cancer growth. Participants were randomly assigned to receive either ripretinib or sunitinib. The study was completed in China and focused on measuring how long patients lived without their cancer getting worse.

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Contacts and locations

Locations

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality, China

  • Chinese PLA General Hospital

    Beijing, Beijing Municipality, China

  • Fudan University Cancer Hospital

    Shanghai, Shanghai Municipality, China

  • Fudan University, Zhongshan Hospital

    Shanghai, Shanghai Municipality, China

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, China

  • Renji Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, Shanghai Municipality, China

  • The 4th Hospital of Hebei Medical University

    Shijiazhuang, Hebei, China

  • The Affiliated Hospital of Haerbin MedicalUniversity

    Harbin, Heilongjiang, China

  • The Affiliated Hospital of Qingdao University

    Qingdao, Shandong, China

  • The Affiliated Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, China

  • The Cancer Hospital of Sun Yat-sen University

    Guangzhou, Guangdong, China

  • The First Affiliated Hospital of Chongqing Medical Universty

    Chongqing, Chognqing, China

  • The First Affiliated Hospital of Sun Yat-sen University

    Guangzhou, Guangdong, China

  • The General Hospital of Peking University

    Beijing, Beijing Municipality, China

  • The sixth Affiliated hospital of Sun Yat-sen University

    Guangzhou, Guangdong, China

  • Union Hospital of HUST

    Wuhan, Hubei, China

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, China

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, China

Conditions

Explore the condition pages connected to this study.