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Can a Two-Drug attack stall resistant prostate cancer?

NCT ID NCT07723248

Recruiting now Disease control Sponsor: ORIC Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether adding an experimental drug called rinzimetostat to the standard drug darolutamide can slow the progression of metastatic castration-resistant prostate cancer better than current treatments. The study enrolls men whose cancer has worsened after treatment with abiraterone. Participants will receive either the combination or a standard therapy chosen by their doctor, and researchers will compare how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combination of rinzimetostat and darolutamide
What this could lead to
If successful, this combination could offer a new treatment option for men with metastatic castration-resistant prostate cancer who have already tried abiraterone.
What could go wrong
This is an early-phase 3 trial, and the combination may not prove more effective than existing therapies. Side effects from the drug combination are also possible.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma Kennedy disease metastatic prostate carcinoma prostate cancer Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION RESISTANT PROSTATE CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Summit Urology

    RECRUITING

    Murray, Utah, 84107, United States

    Contact

  • Urology Specialists of the Carolinas - University Place

    RECRUITING

    Charlotte, North Carolina, 29464, United States

    Contact

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