New drug combo shows promise for Hard-to-Treat ovarian cancer
NCT ID NCT03673124
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing whether the combination of ribociclib (a targeted cancer drug) and letrozole (a hormone therapy) can shrink or stabilize tumors in women with recurrent low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. The study enrolled 51 women and measures how many respond to treatment, as well as side effects. The goal is to find a better option for this rare, slow-growing cancer that often comes back after standard treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ribociclib and letrozole
- What this could lead to
- If successful, this combination could offer a new treatment option for women with recurrent low-grade serous ovarian cancer, potentially slowing disease progression.
- What could go wrong
- This is a small phase II trial with only 51 participants, so results may not apply to all patients. Side effects like low blood cell counts or liver issues are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Abington Memorial Hospital
Willow Grove, Pennsylvania, 19090, United States
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Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 05055, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Houston Methodist Hospital
Houston, Texas, 77479, United States
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Houston Methodist Sugar Land Hospital
Sugar Land, Texas, 77479, United States
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Houston Methodist Willowbrook Hospital
Houston, Texas, 77070, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Memorial Hermann Texas Medical Center - Texas Medical Center
Houston, Texas, 77030, United States
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Miami Valley Hospital
Centerville, Ohio, 45459, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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New Mexico Cancer Care Alliance/University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, 87008, United States
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NorthShore University HealthSystem
Evanston, Illinois, 60201, United States
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Northside Hospital
Atlanta, Georgia, 30342, United States
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Oklahoma Cancer Care Specialists and Research Institute , LLC
Tulsa, Oklahoma, 74146, United States
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Parkland Health and Hospital System
Dallas, Texas, 75235, United States
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Saint Vincent Hospital and Health Care Center, Inc.
Indianapolis, Indiana, 46260, United States
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Southwest Gynecologic Oncology Associates
Albuquerque, New Mexico, 87008, United States
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St. Joseph Mercy Hospital Cancer Care Center
Ann Arbor, Michigan, 48106, United States
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The Ohio State Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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The Valley Hospital Inc.
Ridgewood, New Jersey, 07540, United States
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UF Heath
Gainesville, Florida, 32610, United States
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University of California, San Francisco
San Francisco, California, 94158, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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Western Pennsylvania Hospital/West Penn Hospital
Pittsburgh, Pennsylvania, 15224, United States
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Women & Infants Hospital
Providence, Rhode Island, 02905, United States