Can a plant extract boost testosterone and workout gains?

NCT ID NCT07143474

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether a natural supplement called RhizomK, made from a plant extract, can raise testosterone levels and improve the body's response to exercise in healthy, physically active men aged 21 to 40. Sixty participants will take either RhizomK or a placebo daily, then do a leg press workout. Researchers will measure testosterone and cortisol before and after exercise, along with quality of life. The goal is to see if this supplement offers a safe, natural way to support hormone balance and fitness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
RhizomK (Curculigo orchioides extract)
What this could lead to
If it works, this could point toward a natural supplement to support hormone balance and exercise performance in healthy men.
What could go wrong
This is an early, small study in healthy volunteers, not patients. Results may not be significant or translate to real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 40 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male sex, aged 21 to 40 (inclusive) * Currently engaged in, and has been engaged in resistance training * (i.e., weightlifting), training three or more times per week for at least * the prior 12 months. * Healthy subject (no medical conditions that per the PI assessment). * No significant past medical history * No significant past surgical history that in the opinion of the PI * would preclude study participation. * Passes the screening with Physical Activity Readiness questionnaire (PAR-Q) * Not currently or recently (within the prior eight-weeks) taken a * dietary supplement that is purported to increase testosterone * levels. * Agrees to follow and adhere to the study directions. * Agrees that their study visits will be scheduled at a similar time of the day * to minimize and potential circadian rhythm impacts. Exclusion Criteria: * Takes any prescribed medication or over-the-counter medication which is known to affect testosterone levels. * Positive medical history of heart disease/cardiovascular disease, high blood pressure (140/90 or greater mmHg), kidney disease, hepatic impairment or disease, or Type I or Type II diabetes or any other medical condition or diagnosis that the PI would deem exclusionary. * Positive medical history of unstable thyroid disease, previously diagnosed major affective disorder, psychiatric disorder that required hospitalization in the prior year, immune disorder (i.e., HIV/AIDS), a history of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit. * Positive medical history for any gastrointestinal disease or illness Positive history of gastrointestinal surgery that is known to alter or impact the digestion, absorption of nutrients and or fluids (i.e., gastric bypass). * History of hospitalization or in-patient or out-patient treatment for alcohol dependence or drug addiction over the past one year. * History of hospitalization or in-patient treatment for depression or any mental health related condition within the past one year. * Allergic to any of the ingredients in the study product. * Subject is unwilling to follow study directions.

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As listed by the trial registrant

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How to take part

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  2. The official record

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Contacts and locations

Locations

  • All India Institute of Medical Sciences

    Bhubaneswar, Odisha, 751019, India