Can a plant extract boost testosterone and workout gains?
NCT ID NCT07143474
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether a natural supplement called RhizomK, made from a plant extract, can raise testosterone levels and improve the body's response to exercise in healthy, physically active men aged 21 to 40. Sixty participants will take either RhizomK or a placebo daily, then do a leg press workout. Researchers will measure testosterone and cortisol before and after exercise, along with quality of life. The goal is to see if this supplement offers a safe, natural way to support hormone balance and fitness.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- RhizomK (Curculigo orchioides extract)
- What this could lead to
- If it works, this could point toward a natural supplement to support hormone balance and exercise performance in healthy men.
- What could go wrong
- This is an early, small study in healthy volunteers, not patients. Results may not be significant or translate to real-world benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 40 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male sex, aged 21 to 40 (inclusive) * Currently engaged in, and has been engaged in resistance training * (i.e., weightlifting), training three or more times per week for at least * the prior 12 months. * Healthy subject (no medical conditions that per the PI assessment). * No significant past medical history * No significant past surgical history that in the opinion of the PI * would preclude study participation. * Passes the screening with Physical Activity Readiness questionnaire (PAR-Q) * Not currently or recently (within the prior eight-weeks) taken a * dietary supplement that is purported to increase testosterone * levels. * Agrees to follow and adhere to the study directions. * Agrees that their study visits will be scheduled at a similar time of the day * to minimize and potential circadian rhythm impacts. Exclusion Criteria: * Takes any prescribed medication or over-the-counter medication which is known to affect testosterone levels. * Positive medical history of heart disease/cardiovascular disease, high blood pressure (140/90 or greater mmHg), kidney disease, hepatic impairment or disease, or Type I or Type II diabetes or any other medical condition or diagnosis that the PI would deem exclusionary. * Positive medical history of unstable thyroid disease, previously diagnosed major affective disorder, psychiatric disorder that required hospitalization in the prior year, immune disorder (i.e., HIV/AIDS), a history of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit. * Positive medical history for any gastrointestinal disease or illness Positive history of gastrointestinal surgery that is known to alter or impact the digestion, absorption of nutrients and or fluids (i.e., gastric bypass). * History of hospitalization or in-patient or out-patient treatment for alcohol dependence or drug addiction over the past one year. * History of hospitalization or in-patient treatment for depression or any mental health related condition within the past one year. * Allergic to any of the ingredients in the study product. * Subject is unwilling to follow study directions.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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All India Institute of Medical Sciences
Bhubaneswar, Odisha, 751019, India