One-Time brain injection aims to halt devastating genetic disorder in girls

NCT ID NCT05898620

Summary

This study is testing a one-time gene therapy called NGN-401 for girls with Rett syndrome, a severe genetic disorder that impairs brain development. The therapy delivers a working copy of a missing gene directly to the brain. Researchers will follow participants for 3 years to see if it safely helps them regain developmental skills and improve their condition.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Boston Children's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Email: •••••@•••••

  • Children's Hospital of Philadelphia

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Kennedy Krieger Institute

    RECRUITING

    Baltimore, Maryland, 21205, United States

    Contact Email: •••••@•••••

  • Manchester University NHS Foundation Trust

    TERMINATED

    Manchester, M13 9WL, United Kingdom

  • Montefiore Medical Center

    RECRUITING

    New York, New York, 10467, United States

    Contact Email: •••••@•••••

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

    Contact Email: •••••@•••••

  • Nicklaus Children's Hospital Research Institute

    RECRUITING

    Miami, Florida, 33155, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Royal Hospital for Children and Young People

    TERMINATED

    Edinburgh, EH16 4TJ, United Kingdom

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

    Contact Email: •••••@•••••

  • Texas Children's Hospital

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

  • The Children's Hospital at Westmead

    ACTIVE_NOT_RECRUITING

    Sydney, New South Wales, Australia

  • UCSF Benioff Children's Hospital Oakland

    RECRUITING

    Oakland, California, 94609, United States

    Contact Email: •••••@•••••

  • UNC at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.