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Filler gel shows promise for sunken temples

NCT ID NCT05691972

Symptom relief Sponsor: Galderma R&D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested Restylane Contour, a hyaluronic acid gel, for treating temple hollowing in 225 adults. Participants received either the gel or no treatment. Results showed that the gel improved temple volume, as measured by a 4-point scale. The trial is complete, and the gel appears safe for cosmetic use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Restylane Contour (hyaluronic acid gel with lidocaine)
What this could lead to
If successful, this could provide a safe, effective option for improving the appearance of temple hollowing.
What could go wrong
This is a cosmetic treatment, not a cure for any disease. Results may vary, and risks include allergic reactions or bruising.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

225 people

The number who actually took part.

Started

Mar 2023

Finished

Dec 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males or non-pregnant, non-breastfeeding females, 22 years of age or older * Intent to undergo treatment for correction of temple hollowing Exclusion Criteria: * Known/previous allergy or hypersensitivity to any injectable hyaluronic acid (HA) gel or to gram positive bacterial proteins * Known/previous allergy or hypersensitivity to local anesthetics, e.g., lidocaine or other amide-type anesthetics or nerve blocking agents (if intended to be used for that subject) * Previous facial surgery (e.g., facelift) above the level of the horizontal line from subnasale that in the Treating Investigator´s opinion could interfere with the study safety and/or effectiveness assessments * Any previous aesthetic procedures or implants * Recurrent temporal headaches such as temporal tendinitis migraine. Have a history of migraines or frequent headaches, as determined by the (Treating) Investigator, that could interfere with the study safety and/or effectiveness assessments

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporal hollowing

Contacts and locations

Locations

  • Galderma Research Site

    Phoenix, Arizona, 85054, United States

  • Galderma Research Site

    Encino, California, 91436, United States

  • Galderma Research Site

    Los Angeles, California, 90069, United States

  • Galderma Research Site

    Redondo Beach, California, 90277, United States

  • Galderma Research Site

    Solana Beach, California, 92075, United States

  • Galderma Research Site

    Vista, California, 92083, United States

  • Galderma Research Site

    Washington D.C., District of Columbia, 20037, United States

  • Galderma Research Site

    Adventura, Florida, 33180, United States

  • Galderma Research Site

    Boynton Beach, Florida, 33437, United States

  • Galderma Research Site

    Coral Gables, Florida, 33146, United States

  • Galderma Research Site

    New Orleans, Louisiana, 70115, United States

  • Galderma Research Site

    New York, New York, 10021, United States

  • Galderma Research Site

    Chapel Hill, North Carolina, 27517, United States

  • Galderma Research Site

    Wilmington, North Carolina, 28405, United States

  • Galderma Research Site

    Nashville, Tennessee, 37203, United States