Drug trial for severe pneumonia stopped early after failing to show benefit

NCT ID NCT05254990

Terminated Disease control Sponsor: Dompé Farmaceutici S.p.A Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding an oral drug called reparixin to standard hospital care could help patients with severe pneumonia, including from COVID-19. The goal was to see if it could prevent patients from dying or needing a breathing machine. The trial was stopped early after an analysis found it was unlikely to meet its main goal, but this was not due to safety concerns.

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Contacts and locations

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Locations

AOUP "P.Giaccone" - UOC Pneumologia

Palermo, 90127, Italy
ASST - Ospedale Papa Giovanni XXIII - UOC Pneumologia

Bergamo, 24127, Italy
ASST Grande Ospedale Metropolitano Niguarda Dipartimento Malattie Infettive

Milan, 20162, Italy
ASST SANTI PAOLO E CARLO Ospedale San Paolo Struttura Complessa Malattie Infettive

Milan, 20142, Italy
ASST-Monza Ospedale San Gerardo Malattie Infettive

Monza, 20900, Italy
Acibadem Atakent Hospital

Istanbul, 34303, Turkey (Türkiye)
Ankara City Hospital

Ankara, 06800, Turkey (Türkiye)
Augusta University Health - Augusta University Medical Center

Augusta, Georgia, 30912, United States
Azienda Ospedaliera Universitaria di Bologna - Ospedale Sant'Orsola

Bologna, 40138, Italy
Baptist Hospitals of Southeast Texas

Beaumont, Texas, 77701, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Campus Universitario "Salvatore Venuta", Complesso Clinico, Padiglione B, 8° livello, Pneumologia

Catanzaro, 88100, Italy
Clinica Adventista Belgrano

Buenos Aires, 1430, Argentina
Clinica Independencia

Munro, Buenos Aires, 1605, Argentina
Clinica Pneumologica "L. Vanvitelli" - Osp Monaldi

Naples, 80131, Italy
Denver Health

Denver, Colorado, 80204, United States
Dicle University, Medical Faculty

Diyarbakır, 21280, Turkey (Türkiye)
Dokuz Eylul University Faculty of Medicine

Izmir, 35340, Turkey (Türkiye)
Duke University Hospital

Durham, North Carolina, 27708, United States
Emory Johns Creek Hospital

Atlanta, Georgia, 30342, United States
Fondazione IRCCS Policlinico San Matteo - UOC Pneumologia, Dipartimento di Scienze Mediche e Malattie Infettive

Pavia, 27100, Italy
Gaziantep Universitesi Sahinbey Arastirma Ve Uygulama Hastanesi

Gaziantep, 27310, Turkey (Türkiye)
Helios Hamper-Klinikum Dachau

Dachau, Bavaria, 85221, Germany
Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, 1280, Argentina
Hospital Interzonal General de Agudos Dr Jose Penna

Bahía Blanca, Buenos Aires, 8001, Argentina
Hospital Italiano de Buenos Aires

Ciudad Autonoma de Buenos Aires, Buenos Aires, 1181, Argentina
Hospital Italiano de La Plata

La Plata, Buenos Aires, 1900, Argentina
IRCCS Istituto Clinico Humanitas U.O. Medicina D'Urgenza

Milan, 20089, Italy
IRCCS Ospedale San Raffaele Centro di Ricerca Anestesia e Rianimazione

Milan, 20132, Italy
Inonu Uni.Med.Faculty

Malatya, 44100, Turkey (Türkiye)
Instituto Medico Platense

La Plata, Buenos Aires, 1900, Argentina
Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
KH der Barmherzigen Brüder Linz

Linz, 4020, Austria
Kayseri State Hospital

Kayseri, 38039, Turkey (Türkiye)
Kepler Universitatsklinikum Med Campus III

Linz, 4020, Austria
Klinik Favoriten (Sozialmedizinisches Zentrum Sued - Kaiser-Franz-Josef-Spital mit Gottfried von Preyer'schem Kinderspital)

Vienna, 1100, Austria
Kocaeli Universitesi Tip Fakultesi

Kocaeli, 41380, Turkey (Türkiye)
MD Banner University Medical Center /Arizona University

Tucson, Arizona, 85719, United States
Mater Hospital Brisbane

South Brisbane, Queensland, 4101, Australia
MedStar Health Research Institute-Hyatteville, Maryland

Washington D.C., District of Columbia, 20010, United States
Medizinische Universitaet Wien, Medizinische Klinik I, Abteilung für Infektionskrankheiten und Tropenmedizin

Vienna, 1090, Austria
Mercy Research St Louis

St Louis, Missouri, 63141, United States
Methodist Hospital

Gary, Indiana, 46404, United States
MidMichigan Medical Center - Midland

Midland, Michigan, 48670, United States
NYU Langone Hospital-Brooklyn

Brooklyn, New York, 11220, United States
New York University Langone Health

New York, New York, 10016, United States
Newton-Wellesley Hospital

Newton, Massachusetts, 02462, United States
Northwestern University, Feinberg School of Medicine

Chicago, Illinois, 60611, United States
Nuevo Hospital San Roque

Córdoba, 5000, Argentina
Oregon Health & Science University (OHSU) - Pulmonary Clinic

Portland, Oregon, 97239, United States
Research Alliance Inc.

Clearwater, Florida, 33756, United States
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Sanatorio Agote

Buenos Aires, C1425 EOE, Argentina
Sanatorio Britanico S.A.

Rosario, Santa Fe Province, 2000, Argentina
Sanatorio Finochietto

Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1187, Argentina
Sanatorio Privado Duarte Quiroz De Clinica Colombo SA

Córdoba, 5000, Argentina
Sanatorio Privado de la Cañada - Cordoba

Córdoba, 5000, Argentina
Sanatorio de la Cañada

Villa María, Córdoba Province, 5900, Argentina
Struttura semplice di terapia demi-intensiva respiratoria S.C. di pneumologia AO IRCCS Santa Maria Nuova

Reggio Emilia, 42123, Italy
Texoma Medical Center

Denison, Texas, 75020, United States
UCI Health

Orange, California, 92868, United States
Universitaetsklinikum Carl Gustav Carus TU Dresden

Dresden, Saxony, 01307, Germany
University Hospital - MU Healthcare

Columbia, Missouri, 65212, United States
University Of Genoa - Ospedale Policlinico IRCCS San Martino di Genova

Genova, 16132, Italy
University of Florida-Jacksonville

Jacksonville, Florida, 32209, United States
University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States
University of Utah Hospitals & Clinics

Salt Lake City, Utah, 84108, United States
University of Virginia Medical Center

Charlottesville, Virginia, 22903, United States
Università degli Studi di Milano-Ospedale "L.Sacco" Polo Universitario - ASST Fatebenefratelli Sacco

Milan, 20157, Italy
Universitätsmedizin Göttingen

Göttingen, Südniedersachsen, 37075, Germany
Virginia Commonwealth University Health

Richmond, Virginia, 23298, United States
Washington University, School of Medicine

St Louis, Missouri, 63110, United States
Westmead Hospital

Sydney, New South Wales, 2145, Australia
William Beaumont Hospital

Royal Oak, Michigan, 48073, United States

Conditions

Explore the condition pages connected to this study.

INFECTIOUS PNEUMONIA SEVERE COVID-19