New MS pill aims to outperform standard treatment in major global trial

NCT ID NCT05156281

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 study is testing whether a new oral drug called remibrutinib works better and is as safe as an existing standard oral medication (teriflunomide) for adults with relapsing multiple sclerosis (RMS). About 1011 participants will take one of the two drugs for up to 30 months, with many continuing on remibrutinib for up to 5 more years. The main goal is to see which drug is more effective at reducing the annual rate of MS relapses and slowing disability progression.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Advent Health Orlando

Orlando, Florida, 32803, United States
Aqualane Clinical Research

Naples, Florida, 34105, United States
Ascension St Francis Center

Milwaukee, Wisconsin, 53215, United States
Baptist Physicians Lexington

Nicholasville, Kentucky, 40356, United States
Baylor Scott and White

Temple, Texas, 76508, United States
Brain and Spine Institute

Port Orange, Florida, 32127, United States
CU Anschutz Med Campus

Aurora, Colorado, 80045, United States
Caribbean Center for Clinical Research, Inc

Guaynabo, 00968, Puerto Rico
Clinre Comprehensive Neurology

Frederick, Maryland, 21702, United States
Colorado Neurological Research PC

Denver, Colorado, 80210, United States
Conquest Research

Winter Park, Florida, 32789, United States
Ctr for Neurology and Spine

Phoenix, Arizona, 85018, United States
Elligo Health Research

Crab Orchard, West Virginia, 25827, United States
Emerald Coast Neurology

Pensacola, Florida, 32514, United States
Gables Neurology

Miami, Florida, 33133, United States
Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Georgetown University Hospital Research

Washington D.C., District of Columbia, 20007, United States
Humanity Clinical Research

Pembroke Pines, Florida, 33024, United States
Kansas City VA Medical Center

Kansas City, Missouri, 64128, United States
Lone Star Neurology

Frisco, Texas, 75035, United States
Lonestar Neurology of San Antonio

San Antonio, Texas, 78258, United States
Med Research Inc

El Paso, Texas, 79935, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Healthcare System

Hollywood, Florida, 33021, United States
Methodist Neuroscience Institute

Merrillville, Indiana, 46410, United States
Metrolina Neurological Associates PA

Old Point Station, South Carolina, 29707, United States
Neurology Associates PA

Maitland, Florida, 32751, United States
Neurology Consultants Of Dallas PA

Dallas, Texas, 75231, United States
Neurology Diagnostics Inc

Dayton, Ohio, 45408, United States
New England Institute for Clinical Research

Stamford, Connecticut, 06905, United States
Nova Clinical Research LLC

Bradenton, Florida, 34209, United States
Novartis Investigative Site

Bombal, Mendoza Province, M5500DXO, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, S2000BZL, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, S2000DSW, Argentina
Novartis Investigative Site

San Miguel de, Tucumán Province, T4000, Argentina
Novartis Investigative Site

Buenos Aires, C1012AAR, Argentina
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CABA, C1181ACH, Argentina
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Córdoba, X5004CDT, Argentina
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Vitória, Espírito Santo, 29055-450, Brazil
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Brasília, Federal District, 70200-730, Brazil
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Curitiba, Paraná, 81210-310, Brazil
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Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
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Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
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Porto Alegre, Rio Grande do Sul, 90620-130, Brazil
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Joinville, Santa Catarina, 89202-165, Brazil
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São Paulo, 01240-020, Brazil
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Plovdiv, 4002, Bulgaria
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Sofia, 1309, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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Edmonton, Alberta, T6G 2B7, Canada
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Burnaby, British Columbia, V5G 2X6, Canada
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Halifax, Nova Scotia, B3H 4K4, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Lévis, Quebec, G6W 0M5, Canada
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Montreal, Quebec, H4A 3T2, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Wuhan, Hubei, 430030, China
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Wuhan, Hubei, 430060, China
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Nanjing, Jiangsu, 210029, China
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Yinchuan, Ningxia, 750004, China
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Taiyuan, Shanxi, 030001, China
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Hangzhou, Zhejiang, 310006, China
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Hangzhou, Zhejiang, 310016, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 100034, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Split, HRV, 21000, Croatia
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Varaždin, HRV, 42000, Croatia
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Vukovar, 32000, Croatia
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Zagreb, 10000, Croatia
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Brno, 602 00, Czechia
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Hradec Králové, 500 05, Czechia
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Teplice, 415 29, Czechia
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Tallinn, 11315, Estonia
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Tartu, 50406, Estonia
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Limoges, Haute Vienne, 87000, France
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Toulon, Val De Marne, 83800, France
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Caen, 14033, France
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Clermont-Ferrand, 63003, France
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Dijon, 21000, France
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Gonesse, 95500, France
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Grenoble, 38043, France
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Lille, 59000, France
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Lille, 59037, France
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Nice, 06001, France
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Nîmes, 30029, France
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Poissy, 78303, France
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Toulouse, 31059, France
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Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Essen, 45147, Germany
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Hamburg, 22179, Germany
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Ulm, 89073, Germany
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Athens, 115 28, Greece
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Athens, 11526, Greece
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Chaïdári, 124 62, Greece
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Ioannina, 455 00, Greece
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Larissa, 411 10, Greece
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Thessaloniki, 53246, Greece
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Thessaloniki, 54636, Greece
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Kochi, Kerala, 682025, India
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Pune, Maharashtra, 411013, India
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New Delhi, National Capital Territory of Delhi, 110060, India
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Amritsar, Punjab, 143006, India
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Hyderabad, Telangana, 500082, India
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Lucknow, Uttar Pradesh, 226007, India
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Kolkata, West Bengal, 700017, India
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Brindisi, BR, 72100, Italy
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Foggia, FG, 71122, Italy
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Pozzilli, IS, 86077, Italy
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Messina, ME, 98124, Italy
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Modena, MO, 41126, Italy
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Pavia, PV, 27100, Italy
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Orbassano, TO, 10043, Italy
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Naples, 80138, Italy
Novartis Investigative Site

Nagoya, Aichi-ken, 4668560, Japan
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Ichihara, Chiba, 2990111, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Nishinomiya, Hyōgo, 663 8501, Japan
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Isehara, Kanagawa, 259-1193, Japan
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Sagamihara, Kanagawa, 252-0375, Japan
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Sendai, Miyagi, 9838512, Japan
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Kashihara, Nara, 634 8522, Japan
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Moriguchi, Osaka, 570-8507, Japan
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Suita, Osaka, 5650871, Japan
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Higashi-Matsuyama, Saitama, 355-0005, Japan
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Itabashi-ku, Tokyo, 1738610, Japan
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Kodaira, Tokyo, 187-8551, Japan
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Shinjuku Ku, Tokyo, 160-0023, Japan
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Shinjuku Ku, Tokyo, 1628666, Japan
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Shinjuku-ku, Tokyo, 1608582, Japan
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Chiba, 2608677, Japan
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Fukuoka, 810-0022, Japan
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Fukuoka, 8128582, Japan
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Kobe, 650-0017, Japan
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Kyoto, 616-8255, Japan
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Niigata, 9518520, Japan
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Mexico City, Mexico City, 06700, Mexico
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Chihuahua City, 31203, Mexico
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Mexico City, 14050, Mexico
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Querétaro, 76070, Mexico
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Plewiska, Poznan, 62-064, Poland
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Bialystok, 15-704, Poland
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Glogow Wielkopolski, 36-060, Poland
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Katowice, 40-081, Poland
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Katowice, 40-571, Poland
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Katowice, 40-686, Poland
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Katowice, 40-689, Poland
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Lublin, 20-701, Poland
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Wroclaw, 51-685, Poland
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Zabrze, 41-800, Poland
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Braga, 4710243, Portugal
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Coimbra, 3004-561, Portugal
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Leiria, 2410-197, Portugal
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Lisbon, 1169-050, Portugal
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Lisbon, 1649-035, Portugal
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Matosinhos Municipality, 4454-513, Portugal
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Santa Maria da Feira, 4520-211, Portugal
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Brasov, ROM, 500123, Romania
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Constanța, ROM, 900123, Romania
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Campulung Muscel, 115100, Romania
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Constanța, 900591, Romania
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Banská Bystrica, 974 04, Slovakia
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Banská Bystrica, 975 17, Slovakia
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Bratislava, 833 05, Slovakia
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Celje, 3000, Slovenia
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Ljubljana, 1000, Slovenia
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Maribor, 2000, Slovenia
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Bloemfontein, Free State, 9301, South Africa
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Pretoria, 0041, South Africa
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Rosebank, 2196, South Africa
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Santiago Compostela, A Coruna, 15706, Spain
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Vitoria-Gasteiz, Araba, 01009, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Albacete, Castille-La Mancha, 02006, Spain
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Barcelona, Catalonia, 08003, Spain
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Logroño, La Rioja, 26006, Spain
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Pozuelo de Alarcón, Madrid, 28223, Spain
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Torrejón de Ardoz, Madrid, 28850, Spain
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Gijón, Principality of Asturias, 33394, Spain
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Valencia, Valencia, 46017, Spain
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Barcelona, 08041, Spain
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Lleida, 25198, Spain
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Madrid, 28009, Spain
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Madrid, 28040, Spain
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Málaga, 29016, Spain
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Seville, 41009, Spain
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Valencia, 46026, Spain
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Stockholm, 102 35, Sweden
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Samsun, Atakum, 55200, Turkey (Türkiye)
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Izmir, Balcova, 35340, Turkey (Türkiye)
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Istanbul, Fatih, 34093, Turkey (Türkiye)
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Istanbul, Fatih, 34098, Turkey (Türkiye)
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Izmir, Karabaglar, 35150, Turkey (Türkiye)
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Kayseri, Melikgazi, 38039, Turkey (Türkiye)
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Bursa, Nilufer, 16140, Turkey (Türkiye)
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Istanbul, Pendik, 34899, Turkey (Türkiye)
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Istanbul, Sancaktepe, 34785, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Konya, 42130, Turkey (Türkiye)
Novartis Investigative Site

Inverness, Invernesshire, IV2 3RE, United Kingdom
Novartis Investigative Site

Canterbury, Kent, CT1 3NG, United Kingdom
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Penn State Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Piedmont HealthCare

Charlotte, North Carolina, 28210, United States
Premier Neurology

Greenville, South Carolina, 29605, United States
Regina Berkovich MD PhD Inc

West Hollywood, California, 90048, United States
Sibyl Wray MD Neurology PC

Knoxville, Tennessee, 37922, United States
South Shore Neurologic Associates

Patchogue, New York, 11772, United States
Texas Institute for Neurological Disorders

Sherman, Texas, 75092, United States
The Boster Ctr for MS

Columbus, Ohio, 43235, United States
True North Neurology

Port Jefferson, New York, 11776, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UM Department Of Neurology

Miami, Florida, 33136, United States
UT Health MARC Medical Arts and Research Center

San Antonio, Texas, 78229, United States
University Of NC At Chapel Hill

Chapel Hill, North Carolina, 27599 9500, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Kansas Hospital

Kansas City, Kansas, 66160, United States
University of Washington MS Clinic

Seattle, Washington, 98133, United States
VA Greater LA Healthcare System

Los Angeles, California, 90073, United States
Vero Beach Neurology

Vero Beach, Florida, 32960, United States
Virginia Mason Medical Centre

Seattle, Washington, 98101, United States
Vladimir Royter MD APMC

Hanford, California, 93230, United States

Conditions

Explore the condition pages connected to this study.

RELAPSING MULTIPLE SCLEROSIS