New MS drug trial aims to reduce relapses and slow disability

NCT ID NCT05147220

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an experimental drug called remibrutinib works better than an existing medication (teriflunomide) for people with relapsing multiple sclerosis. About 1,000 participants will take one of these medications for up to 30 months, with the option to continue on remibrutinib for up to 5 more years. The main goal is to see which drug better reduces the frequency of MS attacks and slows the progression of disability.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AZ Integrated Neuro and Spine

Phoenix, Arizona, 85037, United States
Accel Research Sites St Pete-Largo

Seminole, Florida, 33777, United States
Alpine Clinical Research Center

Boulder, Colorado, 80301, United States
American Oncology Partners PA Center for Cancer & Blood Disorders

Bethesda, Maryland, 20817, United States
Arrow Clinical Trials

Daytona Beach, Florida, 32117, United States
Center for Neurosciences

Tucson, Arizona, 85718, United States
Christiana Care Health Services

Newark, Delaware, 19713, United States
College Park Family Care Center

Overland Park, Kansas, 66210, United States
Columbus Neuroscience

Westerville, Ohio, 43082, United States
Comprehensive Neurology Clinic

Orlando, Florida, 32825, United States
Conquest Research

Winter Park, Florida, 32789, United States
DHR Health Institute

McAllen, Texas, 78503, United States
Glendale Adventist Medical Center

Glendale, California, 91206, United States
Hoag Health System

Newport Beach, California, 92663, United States
Homestead Assoc In Research Inc

Homestead, Florida, 33033, United States
IU Health Inc

Fort Wayne, Indiana, 46815, United States
Jersey Shore University Medical Ctr

Neptune City, New Jersey, 07753, United States
John Peter Smith Hospital

Fort Worth, Texas, 76104, United States
MS Center of Greater Washington, P.C.

Vienna, Virginia, 22182, United States
Multiple Sclerosis Center of Excellence of OMRF

Oklahoma City, Oklahoma, 73104, United States
NYU Langone Med Center CV Research

New York, New York, 10016, United States
Neuro Center

Pomona, California, 91767, United States
Neuro Eye Clinical Trials Inc

Houston, Texas, 77074, United States
Neurological Associates of Long Island PC

Lake Success, New York, 11042, United States
Neurological Services of Orlando PA

Orlando, Florida, 32806, United States
Neurology Associates of Ormond Beach

Ormond Beach, Florida, 32174, United States
Neurology Center of New England PC

Foxborough, Massachusetts, 02035, United States
Neurology of Central FL Res Ctr

Altamonte Springs, Florida, 32714, United States
Neuroscience Group

Neenah, Wisconsin, 54956, United States
Neurostudies Inc

Port Charlotte, Florida, 33952, United States
Norton Neurology MS Services

Louisville, Kentucky, 40207, United States
Novartis Investigative Site

Capital Federal, Buenos Aires, 1424, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Buenos Aires, C1012AAR, Argentina
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Buenos Aires, C1055AAF, Argentina
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Caba, C1424BYD, Argentina
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Capital Federal, C1023AAB, Argentina
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Santiago del Estero, 4200, Argentina
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Linz, Upper Austria, 4020, Austria
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Linz, 4020, Austria
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Brussels, Brussels Capital, 1070, Belgium
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Bruges, 8000, Belgium
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Edegem, 2650, Belgium
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Melsbroek, 1820, Belgium
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Overpelt, 3900, Belgium
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Porto Alegre, Porto Alegre RS, 90610 000, Brazil
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Santo André, São Paulo, 09040 010, Brazil
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São Paulo, São Paulo, 01244-030, Brazil
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São Paulo, São Paulo, 04076-004, Brazil
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São Paulo, 01321001, Brazil
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São Paulo, 04550-000, Brazil
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Pleven, 5800, Bulgaria
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Sofia, 1113, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1680, Bulgaria
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Santiago, Santiago Metropolitan, 7650568, Chile
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Santiago, Santiago Metropolitan, 8431657, Chile
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Guangzhou, Guangdong, 510030, China
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Zhengzhou, Henan, 450003, China
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Changsha, Hunan, 410008, China
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Baotou, Inner Mongolia, 014040, China
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Hohhot, Inner Mongolia, 010017, China
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Nanchang, Jiangxi, 330006, China
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Changchun, Jilin, 130021, China
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Beijing, 100053, China
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Beijing, 100730, China
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Chongqing, 400016, China
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Tianjin, 300052, China
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Puerto Colombia, Atlántico, 080012, Colombia
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Cali, Valle del Cauca Department, 760001, Colombia
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Cali, Valle del Cauca Department, 760032, Colombia
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Bogotá, 111411, Colombia
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Medellín, 050001, Colombia
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Medellín, 050034, Colombia
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Osijek, 31000, Croatia
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Rijeka, 51000, Croatia
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Zagreb, 10000, Croatia
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Slagelse, 4200, Denmark
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Tbilisi, 114, Georgia
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Tbilisi, 141, Georgia
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Tbilisi, 159, Georgia
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Tbilisi, 160, Georgia
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Tbilisi, 172, Georgia
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Tbilisi, 179, Georgia
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Guatemala City, 01015, Guatemala
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Shatin, Hong Kong
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Mangalore, Karnataka, 575003, India
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Mangalore, Karnataka, 575018, India
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Mumbai, Maharashtra, 400008, India
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Nashik, Maharashtra, 422005, India
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New Delhi, National Capital Territory of Delhi, 110017, India
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Chandigarh, Punjab, 160012, India
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Ludhiana, Punjab, 141008, India
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Lucknow, Uttar Pradesh, 226014, India
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Dehradun, Uttarakhand, 248001, India
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Dublin, D03 VX82, Ireland
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Dublin, DO4, Ireland
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Ashkelon, 7830604, Israel
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Hadera, 3820302, Israel
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Haifa, 3109601, Israel
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Jerusalem, 9112001, Israel
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Sefad, 1311300, Israel
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Milan, MI, 20132, Italy
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Roma, RM, 00133, Italy
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Roma, RM, 00168, Italy
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Roma, RM, 00189, Italy
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Verona, VR, 37134, Italy
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Novara, 28100, Italy
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Amman, 11942, Jordan
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Riga, LV, LV-1005, Latvia
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Riga, LV 1002, Latvia
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El Chouf, LBN, 1503201002, Lebanon
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Beirut, 166830, Lebanon
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Tripoli, 1434, Lebanon
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Šiauliai, LTU, 76231, Lithuania
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Klaipėda, LT-92288, Lithuania
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Kuala Lumpur, Kuala Lumpur, 50586, Malaysia
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Seberang Jaya, Pulau Pinang, 13700, Malaysia
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Kuching, Sarawak, 93586, Malaysia
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Kuala Terengganu, Terengganu, 20400, Malaysia
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Guadalajara, Jalisco, 44600, Mexico
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San Pedro G G, 66278, Mexico
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Veracruz, 91900, Mexico
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Rotterdam, South Holland, 3079 DZ, Netherlands
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Wroclaw, Lower Silesian Voivodeship, 52-416, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Kielce, 25 726, Poland
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Lodz, 90 324, Poland
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Lodz, 93-113, Poland
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Lublin, 20-410, Poland
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Piotrkow Trybunalski, 97-300, Poland
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Poznan, 60-693, Poland
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Rzeszów, 35-323, Poland
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Szczecin, 70-111, Poland
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Jeddah, 21423, Saudi Arabia
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Jeddah, 21499, Saudi Arabia
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Riyadh, 11426, Saudi Arabia
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Bratislava, 826 06, Slovakia
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Košice, 041 90, Slovakia
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Nitra, 950 01, Slovakia
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Trnava, 917 02, Slovakia
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Cadiz, Andalusia, 11009, Spain
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Seville, Andalusia, 41014, Spain
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Sant Joan Despí, Barcelona, 08970, Spain
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Salt, Girona, 17190, Spain
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Alcorcón, Madrid, 28922, Spain
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Getafe, Madrid, 28905, Spain
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Majadahonda, Madrid, 28222, Spain
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El Palmar, Murcia, 30120, Spain
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Vigo, Pontevedra, 36212, Spain
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Castilleja de la Cuesta, Sevilla, 41950, Spain
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A Coruña, 15006, Spain
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Barcelona, 08035, Spain
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Córdoba, 14004, Spain
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Las Palmas GC, 35010, Spain
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León, 24080, Spain
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Madrid, 28006, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Valladolid, 47011, Spain
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Basel, 4031, Switzerland
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Bern, 3010, Switzerland
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Kaohsiung City, 83301, Taiwan
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Tainan, 704302, Taiwan
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Taipei, 11220, Taiwan
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Taoyuan District, 33305, Taiwan
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Ankara, Bilkent-Cankaya, 06800, Turkey (Türkiye)
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Izmir, Karsiyaka, 35575, Turkey (Türkiye)
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Istanbul, Sultangazi, 34295, Turkey (Türkiye)
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Ankara, Yenimahalle, 06500, Turkey (Türkiye)
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Mersin, Yenisehir, 33110, Turkey (Türkiye)
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Istanbul, 34147, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Abu Dhabi, 00000, United Arab Emirates
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Dubai, United Arab Emirates
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Westbruy on Trym, Bristol, BS10 5NB, United Kingdom
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Winchester, Hampshire, SO23 8SR, United Kingdom
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Glasgow, Scotland, G51 4TF, United Kingdom
Orlando Health Clinical Trials

Orlando, Florida, 32806, United States
Palmetto Clinical Research

Summerville, South Carolina, 29485, United States
Providence St Vincent Med Center

Portland, Oregon, 97225, United States
Reading Hospital

Reading, Pennsylvania, 19611, United States
Reliant Medical Research

Miami, Florida, 33165, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SC3 Research Pasadena

Pasadena, California, 91105, United States
SCL Health

Billings, Montana, 59101, United States
Saturn Research Solutions LLC

Plano, Texas, 75024, United States
Texas Neurology

Dallas, Texas, 75206, United States
The Belinga Clinic

Fort Smith, Arkansas, 72916, United States
The MS Center for Innovation in Care

St Louis, Missouri, 63131, United States
The Neurological Institute PA

Charlotte, North Carolina, 28204, United States
The Neuron Clinic

Chula Vista, California, 91910, United States
The Research and Education Inst. of Alta Bates Summit Med. Grp

Berkeley, California, 94705, United States
University Of Pittsburgh Medical Ctr Magee-Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States
University Of South Florida

Tampa, Florida, 33612, United States
University of Wisconsin Madison

Madison, Wisconsin, 53792, United States
Velocity Clinical Research

Raleigh, North Carolina, 27607, United States
Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Wayne State University Multiple Sclerosis Clinic

Detroit, Michigan, 48201, United States

Conditions

Explore the condition pages connected to this study.

RELAPSING MULTIPLE SCLEROSIS