New pill tested to stop chronic hives triggered by touch, cold, or heat

NCT ID NCT05976243

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing an investigational oral medication called remibrutinib for adults with chronic inducible urticaria (CINDU), a condition where hives are triggered by specific physical stimuli like touch, cold, or heat. The main goal is to see if the drug is more effective than a placebo at controlling hives and itch in people whose symptoms are not well-managed by standard antihistamines. The trial includes a 52-week core study followed by an optional 3-year extension to gather long-term safety and effectiveness data.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Acuro Research Inc

Little Rock, Arkansas, 72205, United States
Aeroallergy Research Laboratories

Savannah, Georgia, 31406, United States
Allergy Associates of Utah

Sandy City, Utah, 84093, United States
Allergy Asthma and Clinical Research

Oklahoma City, Oklahoma, 73120, United States
Allergy and Asthma Specialist P S C

Owensboro, Kentucky, 42301, United States
Allergy and Asthma Specialists Group

Huntington Beach, California, 92647, United States
Allergy and Clinical Immunology Associates

Pittsburgh, Pennsylvania, 15241, United States
Allervie Clinical Research

Birmingham, Alabama, 35209, United States
Antelope Valley Clinical Trials

Lancaster, California, 93534, United States
Asthma and Allergy Associates P C

Colorado Springs, Colorado, 80907, United States
Asthma and Allergy Center of Chicago S C

River Forest, Illinois, 60305, United States
Complete Dermatology

Sugar Land, Texas, 77479, United States
Endeavor Health

Glenview, Illinois, 60077, United States
Florida Ctr Allergy Asthma Research

Aventura, Florida, 33180, United States
John Hopkins University

Baltimore, Maryland, 21204, United States
Kern Research

Bakersfield, California, 93301, United States
National Allergy and Asthma Research LLS

North Charleston, South Carolina, 29420, United States
Novartis Investigative Site

Caba, Buenos Aires, C1121ABE, Argentina
Novartis Investigative Site

CABA, Buenos Aires, C1414AIF, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, 2000, Argentina
Novartis Investigative Site

CABA, C1181ACH, Argentina
Novartis Investigative Site

Woolloongabba, Queensland, 4102, Australia
Novartis Investigative Site

Carlton, Victoria, 3053, Australia
Novartis Investigative Site

Melbourne, Victoria, 3004, Australia
Novartis Investigative Site

Alphaville Barueri, São Paulo, 06454-010, Brazil
Novartis Investigative Site

Santo André, São Paulo, 09060-870, Brazil
Novartis Investigative Site

Sorocaba, São Paulo, 18040-425, Brazil
Novartis Investigative Site

Winnipeg, Manitoba, R3J 0S9, Canada
Novartis Investigative Site

Hamilton, Ontario, L8L 3C3, Canada
Novartis Investigative Site

Trois-Rivières, Quebec, G8T 7A1, Canada
Novartis Investigative Site

Fuzhou, Fujian, 350025, China
Novartis Investigative Site

Guangzhou, Guangdong, 510091, China
Novartis Investigative Site

Guangzhou, Guangdong, 510630, China
Novartis Investigative Site

Changsha, Hunan, 410008, China
Novartis Investigative Site

Wuxi, Jiangsu, 214002, China
Novartis Investigative Site

Changchun, Jilin, 130021, China
Novartis Investigative Site

Jinan, Shandong, 250022, China
Novartis Investigative Site

Chengdu, Sichuan, 610041, China
Novartis Investigative Site

Chengdu, Sichuan, 610072, China
Novartis Investigative Site

Ürümqi, Xinjiang, 830001, China
Novartis Investigative Site

Hangzhou, Zhejiang, 310001, China
Novartis Investigative Site

Yiwu, Zhejiang, 322000, China
Novartis Investigative Site

Beijing, 100050, China
Novartis Investigative Site

Beijing, 100730, China
Novartis Investigative Site

Jinan, 250012, China
Novartis Investigative Site

Shanghai, 200040, China
Novartis Investigative Site

Tianjin, 300052, China
Novartis Investigative Site

Barranquilla, Atlántico, 080002, Colombia
Novartis Investigative Site

Barranquilla, Atlántico, 080020, Colombia
Novartis Investigative Site

Clermont-Ferrand, 63003, France
Novartis Investigative Site

Grenoble, 38043, France
Novartis Investigative Site

Montpellier, 34295, France
Novartis Investigative Site

Nantes, 44093, France
Novartis Investigative Site

Paris, 75970, France
Novartis Investigative Site

Pierre-Bénite, 69495, France
Novartis Investigative Site

Rouen, 76031, France
Novartis Investigative Site

Toulouse, 31400, France
Novartis Investigative Site

Göttingen, Lower Saxony, 37075, Germany
Novartis Investigative Site

Stade, Lower Saxony, 21682, Germany
Novartis Investigative Site

Dresden, Saxony, 01307, Germany
Novartis Investigative Site

Berlin, 13353, Germany
Novartis Investigative Site

Mainz, 55131, Germany
Novartis Investigative Site

Münster, 48149, Germany
Novartis Investigative Site

Tübingen, 72076, Germany
Novartis Investigative Site

Hong Kong, 999999, Hong Kong
Novartis Investigative Site

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site

Debrecen, Hajdú-Bihar, 4031, Hungary
Novartis Investigative Site

Szolnok, Jász-Nagykun-Szolnok, 5000, Hungary
Novartis Investigative Site

Bangalore, Karnataka, 560004, India
Novartis Investigative Site

Mysore, Karnataka, 570001, India
Novartis Investigative Site

Haifa, 3104802, Israel
Novartis Investigative Site

Jerusalem, 9112001, Israel
Novartis Investigative Site

Ramat Gan, 5265601, Israel
Novartis Investigative Site

Tel Aviv, 6423906, Israel
Novartis Investigative Site

Ancona, AN, 60126, Italy
Novartis Investigative Site

Milan, MI, 20122, Italy
Novartis Investigative Site

Rozzano, MI, 20089, Italy
Novartis Investigative Site

Kitakyushu, Fukuoka, 8078556, Japan
Novartis Investigative Site

Sapporo, Hokkaido, 0608543, Japan
Novartis Investigative Site

Kamimashi-gun, Kumamoto, 861-3106, Japan
Novartis Investigative Site

Habikino, Osaka, 5838588, Japan
Novartis Investigative Site

Takatsuki, Osaka, 5698686, Japan
Novartis Investigative Site

Ohtsu, Shiga, 5202192, Japan
Novartis Investigative Site

Izumo, Shimane, 693 8501, Japan
Novartis Investigative Site

Bunkyo-ku, Tokyo, 1138519, Japan
Novartis Investigative Site

Itabashi-ku, Tokyo, 1738610, Japan
Novartis Investigative Site

Shinjuku Ku, Tokyo, 160-0023, Japan
Novartis Investigative Site

Tachikawa, Tokyo, 1900023, Japan
Novartis Investigative Site

Hiroshima, 7308518, Japan
Novartis Investigative Site

Muar town, Johor, 84000, Malaysia
Novartis Investigative Site

Ipoh, Perak, 30450, Malaysia
Novartis Investigative Site

George Town, Pulau Pinang, 10450, Malaysia
Novartis Investigative Site

Utrecht, 3584 CX, Netherlands
Novartis Investigative Site

Bydgoszcz, 85-094, Poland
Novartis Investigative Site

Rzeszów, 35 055, Poland
Novartis Investigative Site

Warsaw, 02-962, Poland
Novartis Investigative Site

Coimbra, 3004-561, Portugal
Novartis Investigative Site

Lisbon, 1649-035, Portugal
Novartis Investigative Site

Vila Nova de Gaia, 4434 502, Portugal
Novartis Investigative Site

Bucharest, District 2, 020762, Romania
Novartis Investigative Site

Singapore, 308205, Singapore
Novartis Investigative Site

Kežmarok, 060 01, Slovakia
Novartis Investigative Site

Trnava, 917 02, Slovakia
Novartis Investigative Site

Žilina, 012 07, Slovakia
Novartis Investigative Site

Suwon, Gyeonggi-do, 16499, South Korea
Novartis Investigative Site

Seoul, 03722, South Korea
Novartis Investigative Site

Santiago, A Coruna, 15702, Spain
Novartis Investigative Site

Granada, Andalusia, 18014, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08003, Spain
Novartis Investigative Site

Alicante, 03010, Spain
Novartis Investigative Site

Barcelona, 08035, Spain
Novartis Investigative Site

Madrid, 28041, Spain
Novartis Investigative Site

Madrid, 280796, Spain
Novartis Investigative Site

Valencia, 46015, Spain
Novartis Investigative Site

Bangkok, 10400, Thailand
Novartis Investigative Site

Bangkok, 10700, Thailand
Novartis Investigative Site

Chiang Mai, 50200, Thailand
Novartis Investigative Site

Sakarya, Adapazari, 54290, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Basaksehir, 34480, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Fatih, 34093, Turkey (Türkiye)
Novartis Investigative Site

Kayseri, Melikgazi, 38039, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Uskudar, 34662, Turkey (Türkiye)
Novartis Investigative Site

Oxford, OX3 7LE, United Kingdom
Novartis Investigative Site

Hanoi, 100000, Vietnam
Novartis Investigative Site

Ho Chi Minh City, 700000, Vietnam
PanAmerican Clinical Research

Brownsville, Texas, 78520, United States
RFSA Dermatology

San Antonio, Texas, 78213, United States
STAAMP Research LLC

San Antonio, Texas, 78229, United States
Sarasota Clinical Research

Sarasota, Florida, 34233, United States
The Indiana Clinical Trials Center

Plainfield, Indiana, 46168, United States
Treasure Valley Medical Research

Boise, Idaho, 83706, United States
Univ of South Florida Asthma Allergy and Immunology CRU

Tampa, Florida, 33613, United States
Western Sky Medical Research

El Paso, Texas, 79924, United States

Conditions

Explore the condition pages connected to this study.

CHRONIC INDUCIBLE URTICARIA