New pill could ease daily struggles of muscle weakness disease

NCT ID NCT06744920

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 10, 2026 · Updated 17 times

Summary

This study tests a new drug called remibrutinib against a placebo in 180 adults with generalized myasthenia gravis, a condition causing muscle weakness. Participants must already be on standard treatments. The goal is to see if the drug improves daily activities and muscle strength over 6 months, with safety monitoring throughout.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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AdventHealth
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Orlando, Florida, 32804, United States

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Center for Neurological Disorders G
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Greenfield, Wisconsin, 53228-1321, United States

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Dent Neurological Institute
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Buffalo, New York, 14209, United States

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Fullerton Neuro and Headache Ctr
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Fullerton, California, 92835, United States

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Homestead Assoc In Research Inc
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Homestead, Florida, 33033, United States

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Honor Health Research Institute
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Scottsdale, Arizona, 85258, United States

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Houston Methodist Hospital
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Houston, Texas, 77030, United States

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Michigan State University-Department of Neurology
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East Lansing, Michigan, 48824, United States

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Mid Atlantic Epilepsy and Sleep Ctr
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Bethesda, Maryland, 20817-1807, United States

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Neurological Services of Orlando PA
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Orlando, Florida, 32806, United States

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Neuromuscular Research Center
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Phoenix, Arizona, 85013, United States

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Novartis Investigative Site
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Rosario, Santa Fe Province, 2000, Argentina
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Caba, C1055AAF, Argentina
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Capital Federal, C1023AAB, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Kogarah, New South Wales, 2217, Australia
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Fitzroy, Victoria, 3065, Australia
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Southport, 4215, Australia
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Leuven, Vlaams Brabant, 3000, Belgium
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Salvador, Estado de Bahia, 40050-410, Brazil
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London, Ontario, N6A 5W9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Hefei, Anhui, 230001, China
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Guangzhou, Guangdong, 510030, China
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Shijiazhuang, Hebei, 50030, China
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Wuhan, Hubei, 430030, China
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Wuxi, Jiangsu, 214023, China
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Changchun, Jilin, 130021, China
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Shanghai, 200040, China
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Shanghai, 200080, China
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Bordeaux, 33076, France
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Nice, 06000, France
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Paris, 75013, France
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Strasbourg, 67081, France
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Toulouse, 31059, France
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Kutaisi, 4600, Georgia
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Tbilisi, 0144, Georgia
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Tbilisi, 114, Georgia
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Hamburg, 20246, Germany
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Gurugram, Haryana, 122011, India
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Mangalore, Karnataka, 575002, India
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Nashik, Maharashtra, 422005, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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Ludhiana, Punjab, 141001, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Lucknow, Uttar Pradesh, 226007, India
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Bergamo, BG, 24127, Italy
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Orbassano, TO, 10043, Italy
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Sapporo, Hokkaido, 0608543, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Nishinomiya, Hyōgo, 6638501, Japan
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Hanamaki, Iwate, 0250082, Japan
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Sendai, Miyagi, 9838520, Japan
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Suita, Osaka, 565-0871, Japan
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Higashi-Matsuyama, Saitama, 355-0005, Japan
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Koshigaya, Saitama, 343-8555, Japan
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Shinjuku Ku, Tokyo, 160-0023, Japan
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Chiba, 2608677, Japan
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Fukushima, 9601295, Japan
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Hiroshima, 7348551, Japan
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Lublin, Lublin Voivodeship, 20-064, Poland
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Lublin, Lublin Voivodeship, 20-080, Poland
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Krakow, POL, 31-505, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Bydgoszcz, 85-065, Poland
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Katowice, 40-689, Poland
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Lodz, 93-113, Poland
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Lublin, 20-410, Poland
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Lublin, 20-701, Poland
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Poznan, 61-731, Poland
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Skorzewo, 60-185, Poland
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Warsaw, 01-684, Poland
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Warsaw, 02-172, Poland
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Brasov, 500283, Romania
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Bucharest, 040215, Romania
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Sibiu, 550245, Romania
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Belgrade, 11000, Serbia
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Niš, 18108, Serbia
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Busan, 49241, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 134 727, South Korea
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Lleida, 25198, Spain
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Madrid, 28034, Spain
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Málaga, 29010, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 83301, Taiwan
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Tainan, 704302, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 111045, Taiwan
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Taoyuan, 33305, Taiwan
SFM Clinical Research LLC
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Boca Raton, Florida, 33487, United States

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UT Health Science Center
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Houston, Texas, 77030, United States

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Univ Cali Irvine ALS Neuromuscular
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Orange, California, 92868, United States

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Univ of Cincinnati Medical Center
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Cincinnati, Ohio, 45219, United States

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University Of Southern California
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Los Angeles, California, 90033, United States

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University of Pittsburgh Medical Center
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Pittsburgh, Pennsylvania, 15213, United States

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University of WA Division of Cardio
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Seattle, Washington, 98195, United States

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Conditions

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GENERALIZED MYASTHENIA GRAVIS