New pill aims to tame debilitating Muscle-Weakening disease

NCT ID NCT06744920

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an oral medication called remibrutinib can help control symptoms and improve daily life for adults with generalized myasthenia gravis (gMG), a chronic autoimmune disease that causes muscle weakness. About 180 participants who are already on stable standard treatments will receive either the study drug or a placebo for 6 months, followed by an option for longer-term treatment. The main goal is to see if the drug safely reduces symptoms like drooping eyelids, double vision, and difficulty with speaking, swallowing, and breathing.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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AdventHealth
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Orlando, Florida, 32804, United States

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Center for Neurological Disorders G
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Greenfield, Wisconsin, 53228-1321, United States

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Dent Neurological Institute
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Buffalo, New York, 14209, United States

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Fullerton Neuro and Headache Ctr
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Fullerton, California, 92835, United States

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Homestead Assoc In Research Inc
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Homestead, Florida, 33033, United States

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Honor Health Research Institute
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Scottsdale, Arizona, 85258, United States

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Houston Methodist Hospital
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Houston, Texas, 77030, United States

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Michigan State University-Department of Neurology
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East Lansing, Michigan, 48824, United States

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Mid Atlantic Epilepsy and Sleep Ctr
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Bethesda, Maryland, 20817-1807, United States

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Neurological Services of Orlando PA
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Orlando, Florida, 32806, United States

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Neuromuscular Research Center
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Phoenix, Arizona, 85013, United States

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Novartis Investigative Site
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Rosario, Santa Fe Province, 2000, Argentina
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Kogarah, New South Wales, 2217, Australia
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Fitzroy, Victoria, 3065, Australia
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Southport, 4215, Australia
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Leuven, Vlaams Brabant, 3000, Belgium
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London, Ontario, N6A 5W9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Guangzhou, Guangdong, 510030, China
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Shijiazhuang, Hebei, 50030, China
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Wuhan, Hubei, 430030, China
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Wuxi, Jiangsu, 214023, China
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Changchun, Jilin, 130021, China
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Shanghai, 200040, China
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Shanghai, 200080, China
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Bordeaux, 33076, France
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Nice, 06001, France
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Paris, 75013, France
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Toulouse, 31059, France
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Kutaisi, 4600, Georgia
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Tbilisi, 0144, Georgia
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Tbilisi, 114, Georgia
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Mangalore, Karnataka, 575002, India
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Nashik, Maharashtra, 422005, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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Ludhiana, Punjab, 141001, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Bergamo, BG, 24127, Italy
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Sapporo, Hokkaido, 0608543, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Nishinomiya, Hyōgo, 663 8501, Japan
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Hanamaki, Iwate, 025-0082, Japan
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Sendai, Miyagi, 983 8520, Japan
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Suita, Osaka, 565 0871, Japan
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Higashi-Matsuyama, Saitama, 355-0005, Japan
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Koshigaya, Saitama, 343-8555, Japan
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Shinjuku Ku, Tokyo, 160-0023, Japan
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Chiba, 260 8677, Japan
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Fukushima, 9601295, Japan
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Hiroshima, 7348551, Japan
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Lublin, Lublin Voivodeship, 20-064, Poland
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Lublin, Lublin Voivodeship, 20-080, Poland
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Krakow, POL, 31-505, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Bydgoszcz, 85-065, Poland
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Katowice, 40-689, Poland
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Lodz, 93-113, Poland
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Lublin, 20-410, Poland
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Lublin, 20-701, Poland
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Poznan, 61-731, Poland
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Skorzewo, 60-185, Poland
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Warsaw, 01-684, Poland
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Warsaw, 02 106, Poland
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Brasov, 500283, Romania
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Bucharest, 040215, Romania
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Sibiu, 550245, Romania
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Seoul, Korea, 03080, South Korea
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Busan, 49241, South Korea
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Seoul, 03722, South Korea
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Seoul, 134 727, South Korea
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Lleida, 25198, Spain
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Madrid, 28034, Spain
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Málaga, 29010, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 83301, Taiwan
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Tainan, 704302, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 111045, Taiwan
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Taoyuan District, 33305, Taiwan
SFM Clinical Research LLC
RECRUITING

Boca Raton, Florida, 33487, United States

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UT Health Science Center
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Houston, Texas, 77030, United States

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Univ Cali Irvine ALS Neuromuscular
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Orange, California, 92868, United States

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Univ of Cincinnati Medical Center
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Cincinnati, Ohio, 45219, United States

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University Of Southern California
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Los Angeles, California, 90033, United States

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University of Pittsburgh Medical Center
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Pittsburgh, Pennsylvania, 15213, United States

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University of WA Division of Cardio
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Seattle, Washington, 98195, United States

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Conditions

Explore the condition pages connected to this study.

GENERALIZED MYASTHENIA GRAVIS