New drug trial aims to ease daily struggles of myasthenia gravis

NCT ID NCT06744920

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 study tests whether remibrutinib can improve daily function in adults with generalized myasthenia gravis, a condition that causes muscle weakness. About 180 participants will receive either the drug or a placebo for 6 months, followed by an open-label phase where everyone gets the drug. The main goal is to see if symptoms and daily activities get better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

remibrutinib

What this could lead to

If it works, this could provide a new treatment option to control symptoms and improve daily life for people with generalized myasthenia gravis.

What could go wrong

This is a Phase 3 trial, but it is still experimental. The drug may not work better than placebo, and side effects are possible. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED MYASTHENIA GRAVIS

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AdventHealth
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Orlando, Florida, 32804, United States

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Sacramento, California, 94115, United States

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Center for Neurological Disorders G
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Greenfield, Wisconsin, 53228-1321, United States

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Cleveland Clinic Foundation
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Cleveland, Ohio, 44195, United States

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Dent Neurological Institute
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Buffalo, New York, 14209, United States

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Fullerton, California, 92835, United States

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Homestead, Florida, 33033, United States

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Honor Health Research Institute
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Scottsdale, Arizona, 85258, United States

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Houston Methodist Hospital
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Houston, Texas, 77030, United States

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Medstar Washington Hospital Center
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Washington D.C., District of Columbia, 20010-2975, United States

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Michigan State University-Department of Neurology
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East Lansing, Michigan, 48824, United States

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Bethesda, Maryland, 20817-1807, United States

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Orlando, Florida, 32806, United States

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Maitland, Florida, 32751, United States

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Boston, Massachusetts, 02114, United States

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Phoenix, Arizona, 85013, United States

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Novartis Investigative Site
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Rosario, Santa Fe Province, 2000, Argentina
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Caba, C1055AAF, Argentina
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Capital Federal, C1023AAB, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Kogarah, New South Wales, 2217, Australia
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Fitzroy, Victoria, 3065, Australia
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Southport, 4215, Australia
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Leuven, Vlaams Brabant, 3000, Belgium
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Salvador, Estado de Bahia, 40050-410, Brazil
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Brasília, Federal District, 70200-730, Brazil
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Caxias do Sul, Rio Grande do Sul, 95070-560, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Porto Alegre, Rio Grande do Sul, 90480-110, Brazil
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São Paulo, 05403-000, Brazil
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Edmonton, Alberta, T6G 2B7, Canada
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London, Ontario, N6A 5W9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Hefei, Anhui, 230001, China
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Guangzhou, Guangdong, 510030, China
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Shijiazhuang, Hebei, 50030, China
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Zhengzhou, Henan, 450003, China
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Wuhan, Hubei, 430030, China
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Wuxi, Jiangsu, 214023, China
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Changchun, Jilin, 130021, China
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Beijing, 100034, China
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Beijing, 100730, China
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Qingdao, 266000, China
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Shanghai, 200040, China
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Shanghai, 200080, China
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Bordeaux, 33076, France
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Nice, 06001, France
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Paris, 75013, France
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Paris, 75940, France
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Strasbourg, 67081, France
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Toulouse, 31059, France
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Kutaisi, 4600, Georgia
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Tbilisi, 0114, Georgia
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Tbilisi, 0144, Georgia
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Frankfurt am Main, Hesse, 60590, Germany
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Gummersbach, 51643, Germany
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Hamburg, 20246, Germany
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Münster, 48149, Germany
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Gurugram, Haryana, 122011, India
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Mangalore, Karnataka, 575002, India
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Nashik, Maharashtra, 422005, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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Ludhiana, Punjab, 141001, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Lucknow, Uttar Pradesh, 226007, India
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Bergamo, BG, 24127, Italy
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Orbassano, TO, 10043, Italy
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Naples, 80131, Italy
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Sapporo, Hokkaido, 0608543, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Nishinomiya, Hyōgo, 6638501, Japan
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Hanamaki, Iwate, 0250082, Japan
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Sendai, Miyagi, 9838520, Japan
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Suita, Osaka, 565-0871, Japan
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Higashi-Matsuyama, Saitama, 355-0005, Japan
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Koshigaya, Saitama, 343-8555, Japan
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Shinjuku Ku, Tokyo, 160-0023, Japan
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Chiba, 2608677, Japan
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Fukuoka, 8128582, Japan
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Fukushima, 9601295, Japan
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Hiroshima, 7348551, Japan
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Lublin, Lublin Voivodeship, 20-064, Poland
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Lublin, Lublin Voivodeship, 20-080, Poland
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Krakow, POL, 31-505, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Bydgoszcz, 85-065, Poland
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Katowice, 40-689, Poland
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Lodz, 93-113, Poland
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Lublin, 20-410, Poland
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Lublin, 20-701, Poland
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Poznan, 61-731, Poland
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Rzeszów, 35-323, Poland
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Skorzewo, 60-185, Poland
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Szczecin, 71-252, Poland
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Warsaw, 01-684, Poland
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Warsaw, 02-172, Poland
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Brasov, 500283, Romania
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Bucharest, 040215, Romania
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Sibiu, 550245, Romania
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Belgrade, 11000, Serbia
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Niš, 18108, Serbia
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Novi Sad, 21000, Serbia
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Busan, 49241, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 134 727, South Korea
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Santiago Compostela, A Coruna, 15706, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Barcelona, 08035, Spain
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Lleida, 25198, Spain
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Madrid, 28034, Spain
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Málaga, 29010, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 83301, Taiwan
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Tainan, 704302, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 111045, Taiwan
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Taoyuan, 33305, Taiwan
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London, NW1 2BU, United Kingdom
SFM Clinical Research LLC
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Boca Raton, Florida, 33487, United States

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UT Health Science Center
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Houston, Texas, 77030, United States

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Univ Cali Irvine ALS Neuromuscular
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Orange, California, 92868, United States

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Univ of Cincinnati Medical Center
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Cincinnati, Ohio, 45219, United States

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University Of Southern California
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Los Angeles, California, 90033, United States

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University of Chicago Medical Centr
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Chicago, Illinois, 60637, United States

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University of Pittsburgh Medical Center
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Pittsburgh, Pennsylvania, 15213, United States

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University of WA Division of Cardio
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Seattle, Washington, 98195, United States

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