New drug trial aims to ease daily struggles of myasthenia gravis

NCT ID NCT06744920

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This Phase 3 study tests whether remibrutinib can improve daily function in adults with generalized myasthenia gravis, a condition that causes muscle weakness. About 180 participants will receive either the drug or a placebo for 6 months, followed by an open-label phase where everyone gets the drug. The main goal is to see if symptoms and daily activities get better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: remibrutinib
What this could lead to: If it works, this could provide a new treatment option to control symptoms and improve daily life for people with generalized myasthenia gravis.
What could go wrong: This is a Phase 3 trial, but it is still experimental. The drug may not work better than placebo, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED MYASTHENIA GRAVIS

Contacts and locations

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Locations

AdventHealth
RECRUITING

Orlando, Florida, 32804, United States
California Pacific Medical Center
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Sacramento, California, 94115, United States
Center for Neurological Disorders G
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Greenfield, Wisconsin, 53228-1321, United States
Cleveland Clinic Foundation
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Cleveland, Ohio, 44195, United States
Dent Neurological Institute
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Buffalo, New York, 14209, United States
Fullerton Neuro and Headache Ctr
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Fullerton, California, 92835, United States
Homestead Assoc In Research Inc
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Homestead, Florida, 33033, United States
Honor Health Research Institute
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Scottsdale, Arizona, 85258, United States
Houston Methodist Hospital
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Houston, Texas, 77030, United States
Massachusetts General Hospital
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Boston, Massachusetts, 02114, United States
Medstar Washington Hospital Center
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Washington D.C., District of Columbia, 20010-2975, United States
Michigan State University-Department of Neurology
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East Lansing, Michigan, 48824, United States
Mid Atlantic Epilepsy and Sleep Ctr
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Bethesda, Maryland, 20817-1807, United States
Neurological Services of Orlando PA
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Orlando, Florida, 32806, United States
Neurology Associates PA
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Maitland, Florida, 32751, United States

Contact Email: •••••@•••••
Neuromuscular Research Center
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Phoenix, Arizona, 85013, United States

Contact Email: •••••@•••••
Novartis Investigative Site
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Rosario, Santa Fe Province, 2000, Argentina
Novartis Investigative Site
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Caba, C1055AAF, Argentina
Novartis Investigative Site
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Capital Federal, C1023AAB, Argentina
Novartis Investigative Site
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San Miguel de Tucumán, T4000AXL, Argentina
Novartis Investigative Site
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Kogarah, New South Wales, 2217, Australia
Novartis Investigative Site
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Fitzroy, Victoria, 3065, Australia
Novartis Investigative Site
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Southport, 4215, Australia
Novartis Investigative Site
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Leuven, Vlaams Brabant, 3000, Belgium
Novartis Investigative Site
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Salvador, Estado de Bahia, 40050-410, Brazil
Novartis Investigative Site
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Brasília, Federal District, 70200-730, Brazil
Novartis Investigative Site
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Caxias do Sul, Rio Grande do Sul, 95070-560, Brazil
Novartis Investigative Site
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Novartis Investigative Site
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Porto Alegre, Rio Grande do Sul, 90480-110, Brazil
Novartis Investigative Site
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São Paulo, São Paulo, 05403-000, Brazil
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Edmonton, Alberta, T6G 2B7, Canada
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London, Ontario, N6A 5W9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Hefei, Anhui, 230001, China
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Guangzhou, Guangdong, 510080, China
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Shijiazhuang, Hebei, 50030, China
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Zhengzhou, Henan, 450003, China
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Wuhan, Hubei, 430030, China
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Wuxi, Jiangsu, 214023, China
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Changchun, Jilin, 130021, China
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Beijing, 100034, China
Novartis Investigative Site
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Beijing, 100730, China
Novartis Investigative Site
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Qingdao, 266000, China
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Shanghai, 200040, China
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Shanghai, 200080, China
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Bordeaux, 33076, France
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Nice, 06000, France
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Paris, 75013, France
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Paris, 75940, France
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Strasbourg, 67081, France
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Toulouse, 31059, France
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Kutaisi, 4600, Georgia
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Tbilisi, 0114, Georgia
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Tbilisi, 0144, Georgia
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Frankfurt am Main, Hesse, 60590, Germany
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Gummersbach, 51643, Germany
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Hamburg, 20246, Germany
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Münster, 48149, Germany
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Gurugram, Haryana, 122011, India
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Mangalore, Karnataka, 575002, India
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Nashik, Maharashtra, 422005, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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Ludhiana, Punjab, 141001, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Lucknow, Uttar Pradesh, 226007, India
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Bergamo, BG, 24127, Italy
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Orbassano, TO, 10043, Italy
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Naples, 80131, Italy
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Chiba, Chiba, 2608677, Japan
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Sapporo, Hokkaido, 0608543, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Nishinomiya, Hyōgo, 6638501, Japan
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Hanamaki, Iwate, 0250082, Japan
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Sendai, Miyagi, 9838520, Japan
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Suita, Osaka, 5650871, Japan
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Higashi-Matsuyama, Saitama, 355-0005, Japan
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Koshigaya, Saitama, 343-8555, Japan
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Shinjuku Ku, Tokyo, 160-0023, Japan
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Fukuoka, 8128582, Japan
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Fukushima, 9601295, Japan
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Hiroshima, 7348551, Japan
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Lublin, Lublin Voivodeship, 20-064, Poland
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Lublin, Lublin Voivodeship, 20-080, Poland
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Krakow, POL, 31-505, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Bydgoszcz, 85-065, Poland
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Katowice, 40-689, Poland
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Lodz, 93-113, Poland
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Lublin, 20-410, Poland
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Lublin, 20-701, Poland
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Poznan, 61-731, Poland
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Rzeszów, 35-323, Poland
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Skorzewo, 60-185, Poland
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Szczecin, 71-252, Poland
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Warsaw, 01-684, Poland
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Warsaw, 02-172, Poland
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Brasov, 500283, Romania
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Bucharest, 040215, Romania
Novartis Investigative Site
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Sibiu, 550245, Romania
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Belgrade, 11000, Serbia
Novartis Investigative Site
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Niš, 18108, Serbia
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Novi Sad, 21000, Serbia
Novartis Investigative Site
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Seoul, Seoul, 03080, South Korea
Novartis Investigative Site
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Busan, 49241, South Korea
Novartis Investigative Site
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Seoul, 03722, South Korea
Novartis Investigative Site
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Seoul, 134 727, South Korea
Novartis Investigative Site
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Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Barcelona, 08035, Spain
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Lleida, 25198, Spain
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Madrid, 28034, Spain
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Málaga, 29010, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 833, Taiwan
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Tainan, 704302, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 111045, Taiwan
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Taoyuan, 33305, Taiwan
Novartis Investigative Site
WITHDRAWN

London, NW1 2BU, United Kingdom
Novartis Investigative Site
RECRUITING

London, SW17 0QT, United Kingdom
SFM Clinical Research LLC
RECRUITING

Boca Raton, Florida, 33487, United States
UT Health Science Center
RECRUITING

Houston, Texas, 77030, United States
Univ Cali Irvine ALS Neuromuscular
RECRUITING

Orange, California, 92868, United States
Univ of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University Of Southern California
RECRUITING

Los Angeles, California, 90033, United States
University of Chicago Medical Centr
RECRUITING

Chicago, Illinois, 60637, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of WA Division of Cardio
RECRUITING

Seattle, Washington, 98195, United States

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