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Vibrating tendons may steady shaky legs — a trial puts it to the test

NCT ID NCT07726043

Symptom relief Sponsor: UGECAM PACA et Corse Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This trial tests whether adding focal tendon vibration to a two-week intensive rehabilitation program can improve balance in adults with Charcot-Marie-Tooth disease type 1A (CMT1A). CMT1A causes progressive muscle weakness and poor balance, often leading to falls. Participants will undergo a multidisciplinary rehab program with or without vibration applied to the quadriceps tendon. The main goal is to see if the vibration-enhanced program leads to better scores on the Berg Balance Scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a 2-week intensive multidisciplinary rehabilitation program combined with focal tendon vibratory stimulation
What this could lead to
If it works, this could point toward a standardized, non-drug therapy to improve balance and reduce falls in people with CMT1A.
What could go wrong
This is a small, early-stage trial with only 30 participants. The vibration technique is still experimental for CMT, and benefits may not be large or long-lasting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals with genetically confirmed Charcot-Marie-Tooth disease type 1A (CMT1A), characterized by PMP22 gene duplication on chromosome 17 (17p11.2). * Age between 18 and 65 years. * Overall Neuropathy Limitations Scale (ONLS) score between 2 and 3/7 for the lower limbs. * Affiliation with a social security/health insurance system. * Written informed consent voluntarily provided after receiving information regarding the study objectives, procedures, and potential risks. Exclusion Criteria: * Comorbidities causing peripheral neuropathy (e.g., diabetes, renal failure, medication-induced neuropathy). * Balance or gait disorders due to another cause. * Individuals without a permanent residence. * Individuals deprived of liberty by judicial or administrative decision or under legal guardianship. * Individuals unable to understand the study objectives and procedures or unable to provide informed consent. * Individuals unable to complete all study procedures. * Previous use of the Vibramoov device. * Pregnant women or women planning to become pregnant during the study period. * Concurrent participation in another research study.

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease type 1A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Charcot-Marie-Tooth disease type 1A

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • IUR Valmante Sud

    RECRUITING

    Marseille, 13009, France

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