New drug combo aims to outperform chemo in Tough-to-Treat stomach cancer
NCT ID NCT04879368
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tested whether a combination of two drugs, regorafenib and nivolumab, helps people with advanced gastro-oesophageal cancer live longer than standard chemotherapy. The study included 462 adults whose cancer had stopped responding to prior treatments. The goal was to see if this new approach could improve overall survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
regorafenib and nivolumab
What this could lead to
If this combination works, it could offer a new treatment option for people with advanced gastro-oesophageal cancer that has stopped responding to standard chemotherapy.
What could go wrong
This is a phase 3 trial, but the results are not yet known. The combination may not improve survival compared to standard chemo, and side effects from both drugs could be significant.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Asan Medical Centre
Seoul, South Korea
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Austin Health
Melbourne, Victoria, 3084, Australia
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Azienda USL-IRCCS Di Reggio Emilia
Reggio Emilia, Italy
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Ballarat Oncology and Haematology Services
Wendouree, New South Wales, 3355, Australia
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Border Medical Oncology Research Unit
East Albury, New South Wales, 2640, Australia
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Caritas Klinikum Saarbrücken St. Theresia
Saarbrücken, Germany
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Charité Universitätsmedizin Berlin
Berlin, Germany
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China Medical University Hospital (CMUH)
Taichung, Taiwan
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Chung-Ang University Hospital
Seoul, South Korea
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Chungbuk National University Hospital
Cheongju-si, South Korea
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Coffs Harbour Health Campus
Coffs Harbour, New South Wales, 2450, Australia
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Concord Repatriation General Hospital
Concord, New South Wales, 2139, Australia
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Dong-A University Hospital
Busan, South Korea
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Evang. Klinikum Bethel Bielefeld
Gütersloh, North Rhine-Westphalia, Germany
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Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
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Fred Hutchinson Cancer Research Centre - South Lake Union Clinic
Seattle, Washington, 98109, United States
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Gosford Hospital
Gosford, New South Wales, 2250, Australia
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Gyeongsang National University Hospital
Jinju, South Korea
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Haeundae Paik Hospital
Busan, South Korea
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Hallym University Sacred Heart Hospital
Anyang, South Korea
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Helios Bad Saarow
Bad Saarow, Germany
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Hokkaido University Hospital
Sapporo, Kita, Japan
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Hospital Clinico Universitario De Valencia
Valencia, Spain
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Hospital Universitario de Navarra
Pamplona, Spain
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IRCCS Fondazione Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy
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Institut für Klinisch Onkol Forschung am Krankenhaus Nordwest
Frankfurt, Germany
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Istituto Nazionale Tumori di Napoli-IRCCS Fondazione G. Pascale
Naples, Italy
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Jeonbuk National University Hospital
Jeonju, South Korea
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KEM/Evang. Kliniken Essen Mitte gGmbH
Essen, Germany
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Kangbuk Samsung Hospital
Seoul, South Korea
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
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Kliniken der Stadt Köln
Cologne, Germany
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Klinikum Bayreuth
Bayreuth, Germany
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Klinikum Leverkusen gGmbH
Leverkusen, Germany
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Klinikum Ludwigburg
Ludwigsburg, Germany
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Klinikum Magdeburg gGmbH
Magdeburg, Germany
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Klinikum rechts der Isar der TU München
München, Germany
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Korea University Anam Hospital
Seoul, South Korea
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Korea University Guro Hospital
Seoul, South Korea
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Kyushu Cancer Center
Fukuoka, Japan
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Landesklinikum Wiener Neustadt
Wiener Neustadt, Austria
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Landeskrankenanstalten-Betriebsgesellschaft-KABEG
Klagenfurt, Austria
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Mayo Clinic Arizona
Scottsdale, Arizona, 85054, United States
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Medizinische Universitaet Wien
Vienna, Austria
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Monash Health
Clayton, Victoria, 3168, Australia
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Monument Health Rapid City Hospital
Rapid City, South Dakota, 57701, United States
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National Cancer Centre Hospital East
Chiba, Kashiwa, Japan
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National Cheng Kung University Hospital
Taipei, Taiwan
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National Taiwan University Hospital (NTUH)
Taipei, Taiwan
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Newcastle Private Hospital
New Lambton Heights, New South Wales, 2035, Australia
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Norddeutsches Studienzentrum für Innovative Onkologie (NIO)
Hamburg, Germany
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Ordensklinikum Linz GmbH Barmherzige schwestern
Linz, Austria
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Philipps-Universitat Marburg
Marburg, Germany
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Port Macquarie Base Hospital
Port Macquarie, New South Wales, 2444, Australia
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Prince of Wales Hospital
Randwick, New South Wales, 2031, Australia
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Royal Brisbane and Womens Hospital
Herston, Queensland, 4029, Australia
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Royal Darwin Hospital
Tiwi, Northern Territory, 0810, Australia
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Royal Hobart Hospital
Hobart, Tasmania, 700, Australia
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Royal North Shore Private Hospital
Sydney, New South Wales, 2065, Australia
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SMG-SNU Boramae Medical Center
Seoul, South Korea
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Saitama Cancer Center
Saitama, Japan
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San Camillo Forlanini Hospitals
Roma, Italy
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Seoul National University Bundang Hospital
Seoul, South Korea
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Seoul National University Hospital
Seoul, South Korea
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Shikoku Cancer Center
Matsuyama, Japan
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Shizuoka Cancer Center
Shizuoka, Japan
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Siouxland Regional Cancer Center
Sioux City, Iowa, 51101, United States
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Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009, Australia
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St Elizabeth Healthcare
Edgewood, Kentucky, 41017, United States
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St George Hospital
Kogarah, New South Wales, 2217, Australia
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St John of God Hospital Subiaco
Subiaco, Western Australia, 6008, Australia
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St Vincent's Public Hospital
Darlinghurst, New South Wales, 2010, Australia
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Studienzentrum Onkologie Ravensburg
Ravensburg, Germany
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Sunshine Coast University Hospital
Sunshine Coast, Queensland, 4560, Australia
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Taipei Veterans General Hospital (TPVGH)
Taipei, Taiwan
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The Catholic University of Korea - Seoul St. Mary's Hospital
Seoul, South Korea
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The Catholic University of Korea - Yeouido St. Mary's Hospital
Seoul, South Korea
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The Queen Elizabeth Hospital
Adelaide, South Australia, 5011, Australia
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The Townsville Hospital
Douglas, Queensland, 4814, Australia
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The Tweed Hospital
Tweed Heads, New South Wales, 2485, Australia
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USC Norris
Los Angeles, California, 90001, United States
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Universita Cattolica del Sacro Cuore, University Hospital Gemelli
Roma, Italy
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Universitae degli studi della Campania "Luigi Vanvitelli"
Naples, Italy
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Universitätsklinikum Bonn
Bonn, Germany
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Universitätsklinikum Greifswald
Greifswald, Germany
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Universitätsklinikum Heidelberg
Heidelberg, Germany
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Universitätsklinikum Jena
Jena, Germany
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Universitätsklinikum Leipzig
Leipzig, Germany
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Universitätsklinikum Mainz
Mainz, Germany
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Universitätsklinikum Ulm
Ulm, Germany
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Vall d'Hebron University Hospital
Barcelona, Spain
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
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Yonsei University Health System - Gangnam Severance Hospital
Seoul, South Korea
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Yonsei University Health System - Severance Hospital
Seoul, South Korea