A new filler takes on deep smile lines — can it match the standard?
NCT ID NCT07736703
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This trial tests whether a new hyaluronic acid filler called RefillHA Solid works as well as an existing filler, Hydryalix Ultra Deep Lidocaine, for smoothing moderate-to-severe nasolabial folds (the lines from the nose to the corners of the mouth). Each participant receives both fillers — one on each side of the face — so the results can be compared directly. The study is small, with 12 adults, and focuses on safety and how well each filler reduces wrinkle severity over 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hyaluronic acid hydrogel with lidocaine injectable implant
- What this could lead to
- If the new filler works as well as the existing one, it could offer another option for smoothing deep smile lines.
- What could go wrong
- This is a very small, early-stage trial with only 12 participants, so results may not apply broadly. As with any injectable filler, risks include swelling, bruising, or uneven results.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Glyance Ltd
Lod, Israel, 7152026, Israel