New device offers hope for patients with untreatable chest pain

NCT ID NCT02710435

First seen Nov 18, 2025 · Last updated May 14, 2026 · Updated 18 times

Summary

This study tracks 400 people with chronic chest pain (angina) who have not improved with standard treatments and cannot have bypass surgery or stents. The goal is to see if the Reducer device safely reduces chest pain over several years. Researchers will measure symptom improvement and any serious heart events.

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Contacts and locations

Locations

  • Bolognini General Hospital

    Seriate, 24068, Italy

  • Bradford Royal Infirmary

    Bradford, BD9 6RJ, United Kingdom

  • Contilia Heart and Vascular Centre, Elisabeth Krankenhaus Essen, Klinik fϋr Kardiologie und Angiologie

    Essen, 45138, Germany

  • Dresden University

    Dresden, 01307, Germany

  • HFR Fribourg/University of Fribourg

    Fribourg, 1708, Switzerland

  • Hopitaux Universitaires Geneve (HUG)

    Geneva, 1205, Switzerland

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Institut Coeur Poumon

    Lille, France

  • Istituto Cardiocentro Ticino

    Lugano, 6900, Switzerland

  • Kerckhoff Klinik

    Bad Nauheim, 61231, Germany

  • King's College Hospital

    London, SE5 9RS, United Kingdom

  • Royal Brompton Hospital

    London, SW3 6NP, United Kingdom

  • Royal Infirmary of Edinburgh

    Edinburgh, EH16 4SA, United Kingdom

  • San Raffaele Hospital

    Milan, 20132, Italy

  • St. Antonius Ziekenhuis

    Nieuwegein, 3435CM, Netherlands

  • St. Thomas Hospital

    London, SE1 7EH, United Kingdom

  • UMC Utrecht

    Utrecht, 3584 CX, Netherlands

  • University Giessen

    Giessen, 35392, Germany

  • University Heart Center Freiburg - Bad Krozingen

    Freiburg im Breisgau, 79106, Germany

  • University Heart Center Hamburg

    Hamburg, 20246, Germany

  • University Hospital Basel

    Basel, CH-4031, Switzerland

  • University Hospital of Brest

    Brest, France

  • University of Graz

    Graz, 8010, Austria

  • ZNA Middelheim Hospital

    Antwerp, 2020, Belgium

  • Zienkenhuis Oost-Limburg

    Genk, 3600, Belgium

Conditions

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