Triple threat: radiation, chemo, and immunotherapy join forces against advanced rectal cancer
NCT ID NCT06787183
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether a short course of radiation followed by two cycles of chemotherapy (CAPOX) plus an experimental immunotherapy drug (QL1706) can help people with rectal cancer that has spread to the liver. The study will enroll 42 adults aged 18-75 who have not had prior treatment. The main goal is to see how long the cancer stays under control, while also monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
QL1706 (a bispecific antibody targeting PD-1 and CTLA-4), capecitabine, oxaliplatin, and short-course radiotherapy
What this could lead to
If successful, this combination could offer a new, more effective treatment option for people with rectal cancer that has spread to the liver, potentially improving how long they live without the cancer growing.
What could go wrong
This is a small, early-phase trial (42 people) with no control group, so results may not apply broadly. The combination of radiation, chemotherapy, and immunotherapy can cause significant side effects, including severe immune-related reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fujian Cancer Hospital
RECRUITINGFuzhou, Fujian, 350014, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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Fuzhou First General Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, 350004, China
Contact Phone: •••-•••-••••