Drug trial aims to protect kidneys in autoimmune diseases

NCT ID NCT04564339

Terminated Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether the drug ravulizumab could help control kidney damage in adults with lupus nephritis or IgA nephropathy. About 123 participants were randomly assigned to receive either the drug or a placebo infusion to see if it safely reduced protein in their urine, a key sign of kidney injury. The trial was terminated early, and its main goal was to see if blocking a part of the immune system could slow these serious kidney diseases.

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Contacts and locations

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Locations

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San Dimas, California, 91773, United States
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Santa Monica, California, 90404, United States
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South Gate, California, 90280, United States
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Stanford, California, 94305, United States
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Orlando, Florida, 32835, United States
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Plantation, Florida, 33324, United States
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Lawrenceville, Georgia, 30046, United States
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Lexington, Kentucky, 40536, United States
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Louisville, Kentucky, 40202, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02115, United States
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Kansas City, Missouri, 64111, United States
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New York, New York, 10003, United States
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Chapel Hill, North Carolina, 27599, United States
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Columbus, Ohio, 43203, United States
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El Paso, Texas, 79935, United States
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Houston, Texas, 77054, United States
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Herston, 4029, Australia
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Parkville, 3050, Australia
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Westmead, 2145, Australia
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London, Ontario, N6A 5W9, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Québec, Quebec, G1R 2J6, Canada
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Clermont-Ferrand, 63003, France
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Le Kremlin-Bicêtre, 94270, France
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Paris, 75020, France
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Saint-Priest-en-Jarez, 42270, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Berlin, 10117, Germany
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Essen, 45147, Germany
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Hanover, 30625, Germany
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Lübeck, 23538, Germany
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Bologna, 40138, Italy
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Brescia, 25123, Italy
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Florence, 50134, Italy
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Torino, 10154, Italy
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Maastricht, 6229 HX, Netherlands
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Lodz, 92-213, Poland
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Anyang-si, 14068, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 134-727, South Korea
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Seoul, 6591, South Korea
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Lleida, 25198, Spain
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Madrid, 28007, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Palma de Mallorca, 07010, Spain
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Seville, 41013, Spain
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Valencia, 46017, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 833401, Taiwan
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New Taipei City, 23561, Taiwan
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Taichung, 40447, Taiwan
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Edgbaston, B15 2WB, United Kingdom
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London, SE1 7EH, United Kingdom
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London, W12 0HS, United Kingdom
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Salford, M6 8HD, United Kingdom

Conditions

Explore the condition pages connected to this study.

IMMUNOGLOBULIN A NEPHROPATHY LUPUS NEPHRITIS