New cell therapy could tame severe muscle disease
NCT ID NCT06665256
First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 26 times
Summary
This study tests a new treatment called rapcabtagene autoleucel for people with severe idiopathic inflammatory myopathies (IIM), a group of diseases causing muscle inflammation and weakness. About 123 adults aged 18 to 75 who haven't improved with standard therapies will be randomly assigned to receive either the new cell therapy or a comparator. The main goal is to see if more participants achieve moderate-to-major improvement in muscle function after 52 weeks.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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FL Medical Clinic Orlando Health
RECRUITINGZephyrhills, Florida, 33542, United States
Contact
Contact Email: •••••@•••••
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LDS Hospital
RECRUITINGSalt Lake City, Utah, 84143, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact
Contact
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Novartis Investigative Site
RECRUITINGBrest, 29200, France
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Novartis Investigative Site
SUSPENDEDLille, 59037, France
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Novartis Investigative Site
RECRUITINGLyon, 69003, France
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Novartis Investigative Site
RECRUITINGParis, 75013, France
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Novartis Investigative Site
RECRUITINGRennes, 35033, France
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Novartis Investigative Site
RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
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Novartis Investigative Site
RECRUITINGLeipzig, Saxony, 04103, Germany
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Novartis Investigative Site
RECRUITINGJena, Thuringia, 07740, Germany
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Novartis Investigative Site
RECRUITINGAachen, 52074, Germany
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Novartis Investigative Site
RECRUITINGHamburg, 20246, Germany
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Novartis Investigative Site
RECRUITINGMainz, 55131, Germany
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Novartis Investigative Site
RECRUITINGNuremberg, 90419, Germany
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Novartis Investigative Site
RECRUITINGUlm, 89081, Germany
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Novartis Investigative Site
RECRUITINGHaifa, 3109601, Israel
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Novartis Investigative Site
RECRUITINGRamat Gan, 5265601, Israel
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Novartis Investigative Site
RECRUITINGTel Aviv, 6423906, Israel
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Novartis Investigative Site
RECRUITINGBrescia, BS, 25123, Italy
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Novartis Investigative Site
RECRUITINGMonza, MB, 20900, Italy
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Novartis Investigative Site
RECRUITINGMilan, MI, 20122, Italy
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Novartis Investigative Site
RECRUITINGSapporo, Hokkaido, 0608648, Japan
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Novartis Investigative Site
RECRUITINGKanazawa, Ishikawa-ken, 920 8641, Japan
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Novartis Investigative Site
RECRUITINGYokohama, Kanagawa-ku, 236-0004, Japan
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Novartis Investigative Site
RECRUITINGSendai, Miyagi, 9808574, Japan
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Novartis Investigative Site
RECRUITINGSuita, Osaka, 565 0871, Japan
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Novartis Investigative Site
RECRUITINGIzumo, Shimane, 693 8501, Japan
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Novartis Investigative Site
RECRUITINGBunkyo-ku, Tokyo, 113-8603, Japan
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Novartis Investigative Site
RECRUITINGBunkyo-ku, Tokyo, 1138519, Japan
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Novartis Investigative Site
RECRUITINGShinjuku-ku, Tokyo, 1608582, Japan
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Novartis Investigative Site
RECRUITINGFukuoka, 8128582, Japan
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Novartis Investigative Site
RECRUITINGKyoto, 6068507, Japan
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Novartis Investigative Site
RECRUITINGAmsterdam, North Holland, 1105 AZ, Netherlands
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Novartis Investigative Site
RECRUITINGRiyadh, 11211, Saudi Arabia
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Novartis Investigative Site
RECRUITINGSingapore, 119074, Singapore
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Novartis Investigative Site
RECRUITINGSingapore, 169608, Singapore
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Novartis Investigative Site
RECRUITINGSingapore, S308433, Singapore
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Novartis Investigative Site
RECRUITINGSantiago Compostela, A Coruna, 15706, Spain
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Novartis Investigative Site
RECRUITINGSantander, Cantabria, 39008, Spain
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Novartis Investigative Site
RECRUITINGPamplona, Navarre, 31008, Spain
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Novartis Investigative Site
RECRUITINGBarcelona, 08035, Spain
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Novartis Investigative Site
RECRUITINGCórdoba, 14004, Spain
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Novartis Investigative Site
RECRUITINGMadrid, 28041, Spain
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Novartis Investigative Site
RECRUITINGMálaga, 29010, Spain
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Novartis Investigative Site
RECRUITINGSalamanca, 37007, Spain
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Novartis Investigative Site
RECRUITINGGeneva, 1211, Switzerland
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Novartis Investigative Site
RECRUITINGKaohsiung City, 83301, Taiwan
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Novartis Investigative Site
RECRUITINGTaichung, 407219, Taiwan
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Novartis Investigative Site
RECRUITINGTaipei, 10002, Taiwan
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Novartis Investigative Site
RECRUITINGSheffield, South Yorkshire, S10 2JF, United Kingdom
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Novartis Investigative Site
RECRUITINGLondon, NW1 2BU, United Kingdom
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University Of Alabama
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
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