One-Time cell therapy could tame tough lupus

NCT ID NCT06581198

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a one-time treatment called rapcabtagene autoleucel, made from a patient's own immune cells, for people with active lupus or lupus kidney disease that hasn't improved with standard therapies. About 179 adults will receive the treatment after a short chemotherapy prep. The goal is to see if it can put lupus into remission or improve kidney function without needing lifelong medication, though ongoing monitoring for side effects is required.

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Conditions

The condition(s) this trial relates to.

lupus nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS NEPHRITIS

Contacts and locations

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Ann and Robert H Lurie Childs Hosp
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Chicago, Illinois, 60611, United States

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Boston Medical Center
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Boston, Massachusetts, 02118, United States

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Duke Clinical Research Institute
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Durham, North Carolina, 27710, United States

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Houston Methodist Hospital
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Houston, Texas, 77030, United States

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LDS Hospital
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Salt Lake City, Utah, 84143, United States
LDS Hospital
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Salt Lake City, Utah, 84143, United States

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Loma Linda University
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San Bernardino, California, 92408, United States

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Northwestern University
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Chicago, Illinois, 60611, United States

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Novartis Investigative Site
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Clayton, Victoria, 3168, Australia
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Graz, 8036, Austria
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Vienna, 1090, Austria
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Salvador, Estado de Bahia, 41253-190, Brazil
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Barretos, São Paulo, 14784 400, Brazil
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São Paulo, São Paulo, 01232-010, Brazil
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São Paulo, São Paulo, 01308-050, Brazil
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São Paulo, 01509-010, Brazil
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Olomouc, 779 00, Czechia
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Prague, 128 00, Czechia
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Prague, 128 08, Czechia
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Aarhus N, 8200, Denmark
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Bordeaux, 33076, France
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Clermont-Ferrand, 63003, France
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Marseille, 13005, France
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Nantes, 44093, France
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Paris, 75013, France
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Paris, 75014, France
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Strasbourg, 67091, France
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Toulouse, 31054, France
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Vandœuvre-lès-Nancy, 54511, France
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Stuttgart, Baden-Wurttemberg, 70376, Germany
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Frankfurt am Main, Hesse, 60528, Germany
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Cologne, North Rhine-Westphalia, 50937, Germany
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Leipzig, Saxony, 04103, Germany
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Jena, Thuringia, 07740, Germany
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Essen, 45147, Germany
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Lübeck, 23538, Germany
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Mainz, 55131, Germany
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Nuremberg, 90419, Germany
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Ulm, 89081, Germany
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Budapest, H-1083, Hungary
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Haifa, 3109601, Israel
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Ramat Gan, 5265601, Israel
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Tel Aviv, 6423906, Israel
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Alessandria, AL, 15121, Italy
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Ancona, AN, 60126, Italy
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Genova, GE, 16132, Italy
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Milan, MI, 20122, Italy
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Milan, MI, 20132, Italy
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Rozzano, MI, 20089, Italy
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Pescara, PE, 65124, Italy
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Pisa, PI, 56126, Italy
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Pavia, PV, 27100, Italy
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Sapporo, Hokkaido, 060-8648, Japan
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Kobe, Hyōgo, 6500047, Japan
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Yokohama, Kanagawa, 236-0004, Japan
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Sendai, Miyagi, 9808574, Japan
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Suita, Osaka, 565-0871, Japan
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Izumo, Shimane, 6938501, Japan
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Bunkyo Ku, Tokyo, 1138431, Japan
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Bunkyo-ku, Tokyo, 1138519, Japan
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Chiba, 2608677, Japan
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Fukuoka, 8128582, Japan
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Ishikawa, 9208641, Japan
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Kyoto, 6068507, Japan
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Leiden, South Holland, 2333 ZA, Netherlands
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Groningen, 9713 GZ, Netherlands
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Utrecht, 3584 CX, Netherlands
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Oslo, 0372, Norway
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Bucharest, 022328, Romania
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Riyadh, 11211, Saudi Arabia
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Singapore, 119074, Singapore
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Seoul, 04763, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Santiago Compostela, A Coruna, 15706, Spain
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Santander, Cantabria, 39008, Spain
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Pamplona, Navarre, 31008, Spain
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Barcelona, 08035, Spain
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Córdoba, 14004, Spain
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Madrid, 28009, Spain
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Madrid, 28041, Spain
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Salamanca, 37007, Spain
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Valencia, 46026, Spain
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Stockholm, 17176, Sweden
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Lausanne, 1011, Switzerland
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Taichung, 407219, Taiwan
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Taipei, 10002, Taiwan
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Sheffield, South Yorkshire, S10 2JF, United Kingdom
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London, W12 0HS, United Kingdom
Oregon Health Sciences University
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Portland, Oregon, 97239, United States

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Sutter Health Network
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San Pablo, California, 94806, United States

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Tufts Medical Center
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Boston, Massachusetts, 02111, United States

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UCSF
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San Francisco, California, 94115, United States
UCSF
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San Francisco, California, 94115, United States

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Univ Of TX MD Anderson CC
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Houston, Texas, 77030, United States

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University Of Alabama
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Birmingham, Alabama, 35294, United States

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University Of Iowa
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Iowa City, Iowa, 52242, United States

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University of Kentucky
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Lexington, Kentucky, 40536-0284, United States

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University of Texas MD Anderson Cancer Center
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Houston, Texas, 77030, United States

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WA Uni School Of Med
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St Louis, Missouri, 63110, United States

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