New drug shows promise for Tough-to-Treat seizures

NCT ID NCT06377930

First seen Feb 05, 2026 · Last updated May 15, 2026 · Updated 16 times

Summary

This study tested an experimental drug called RAP-219 in 30 adults with refractory focal epilepsy, a type of epilepsy that doesn't respond well to standard treatments. All participants had a brain implant to monitor seizures. The goal was to see if RAP-219 could safely reduce the number of seizures. The study is now complete.

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Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 770300, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Consultants in Epilepsy and Neurology, PLLC

    Boise, Idaho, 83702, United States

  • IU Health Neuroscience Center, Goodman Hall

    Indianapolis, Indiana, 46202, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • NYU Langone Comprehensive Epilepsy Center

    New York, New York, 10016, United States

  • The University of Kansas Medical Center Epilepsy Clinic

    Kansas City, Kansas, 66160, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • University of Pennsylvania - Department of Neurology

    Philadelphia, Pennsylvania, 19104, United States

  • University of Texas Health Science Center, Houston

    Houston, Texas, 77030, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Yale University

    New Haven, Connecticut, 06519, United States

Conditions

Explore the condition pages connected to this study.