Promising new drug targets seizures in rare GRIN disorder

NCT ID NCT07224581

Recruiting now Disease control Sponsor: GRIN Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 4 times

Summary

This study tests a drug called radiprodil in people with GRIN-related neurodevelopmental disorder, a rare genetic condition that often causes seizures and developmental delays. The trial includes two groups: one with frequent seizures and one with fewer or no seizures. Participants are randomly assigned to receive radiprodil or a placebo for 16 to 28 weeks, followed by an open-label phase where everyone can get the active drug. The goal is to see if radiprodil reduces seizures and improves other symptoms safely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiprodil
What this could lead to: If successful, radiprodil could become the first targeted treatment to reduce seizures and improve daily function in people with GRIN-related neurodevelopmental disorder.
What could go wrong: This is an early-stage Phase 3 trial with only 100 participants, so results may not apply to everyone. The drug may cause side effects or fail to show clear benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Azienda Ospedaliera Universitaria Meyer IRCCS
RECRUITING

Florence, Viale Pieraccini, 24, Italy
Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CHU Toulouse - Hôpital Purpan
RECRUITING

Toulouse, Cedex 9, France
Centre Hospitalier Universitaire d'Angers (CHU Angers)
RECRUITING

Angers, 49933, France
Child Neurology Consultants of Austin - South Austin
RECRUITING

Austin, Texas, 78757, United States
Children's Hospital Colorado - Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center
NOT_YET_RECRUITING

Cincinnati, Ohio, 45229, United States
Columbia University - Harkness
RECRUITING

New York, New York, 10032, United States
Duke Health-Duke Children's Hospital & Health Center
RECRUITING

Durham, North Carolina, 27705, United States
Erasmus MC (Erasmus Universitair Medisch Centrum Rotterdam)
RECRUITING

Rotterdam, South Holland, Netherlands
Great Ormond Street Hospital For Children NHS Foundation Trust
RECRUITING

London, G51 4TF, United Kingdom
Hospices Civils De Lyon
RECRUITING

Bron, 69677, France
Hospital Sant Joan de Deus
RECRUITING

Esplugues de Llobregat, Barcelona, Spain
Hôpital Necker Enfants Malades
RECRUITING

Paris, 75743, France
IRCCS Fondazione Istituto Neurologico Nazionale Casimiro Mondino
RECRUITING

Pavia, Italy
Institute of Polish Mother's Health Center (Instytut Centrum Zdrowia Matki Polki)
RECRUITING

Lodz, 93-338, Poland
Iowa Health Care - Pediatric Neurology & Specialty Clinic
RECRUITING

Iowa City, Iowa, 52242, United States
Klinik und Policlinik fur Kinder - und Jugendmedizin
RECRUITING

Leipzig, 04103, Germany
Lucile Packard Children's Hospital
RECRUITING

Palo Alto, California, 94304, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Northeast Regional Epilepsy Group (NEREG) - Hackensack
RECRUITING

Hackensack, New Jersey, 07601, United States
Ospedale Pediatrico Bambino Gesu
RECRUITING

Roma, 00165, Italy
Pediatric Neurology and Epilepsy
RECRUITING

Winter Park, Florida, 32789, United States
Royal Hospital for Children Glasgow
RECRUITING

Glasgow, United Kingdom
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Sheffield Children's Hospital NHS Foundation Trust
RECRUITING

Sheffield, South Yorkshire, United Kingdom
The University of Texas Southwestern Medical Center (UTSW)
RECRUITING

Dallas, Texas, 75390, United States
UCLA Health - Ronald Reagan UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
UTHealth Houston
RECRUITING

Houston, Texas, 77030, United States
UZ Brussel
RECRUITING

Brussels, 1090, Belgium
Universitatsmedizin Greifswald Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe
RECRUITING

Greifswald, Germany
University Children's Hospital
RECRUITING

Ljubljana, 1525, Slovenia