New hope for frail lung cancer patients: no chemo needed

NCT ID NCT04351256

First seen Dec 18, 2025 · Last updated Jun 18, 2026 · Updated 26 times

Summary

This study tested a combination of radiation therapy and the immunotherapy drug durvalumab in 51 elderly or frail patients with stage III lung cancer who could not receive chemotherapy. The goal was to see if this approach could control the cancer with manageable side effects. Results focused on lung inflammation and tumor response at 3 months.

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Contacts and locations

Locations

  • DRK Kliniken Berlin-Mitte

    Berlin, 13359, Germany

  • Gemeinschaftspraxis für Hämatologie und Onkologie

    Münster, 48153, Germany

  • Kliniken Maria Hilf GmbH

    Mönchengladbach, 41063, Germany

  • Kliniken der Stadt Köln gGmbH, Lungenklinik Merheim

    Cologne, 51109, Germany

  • Klinikum Ludwigsburg

    Ludwigsburg, 71640, Germany

  • Lungenklinik Hemer, Pneumologie und Thorakale Onkologie

    Hemer, 58675, Germany

  • Onkodok GmbH

    Gütersloh, 33332, Germany

  • Pi.Tri-Studien GmbH

    Offenburg, 77654, Germany

  • Sana Klinikum Offenbach GmbH

    Offenbach, 63069, Germany

  • Thoraxklinik am Universitätsklinikum Heidelberg

    Heidelberg, 69126, Germany

  • Universitätsklinikum Aachen

    Aachen, 52074, Germany

  • Universitätsmedizin Göttingen

    Göttingen, 37075, Germany

  • Universitätsmedizin Mainz

    Mainz, 55131, Germany

  • Vincentius-Diakonissen-Kliniken gAG

    Karlsruhe, 76137, Germany

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.