New hope for frail lung cancer patients: targeted radiation plus immunotherapy without chemo

NCT ID NCT04351256

First seen Dec 18, 2025 · Last updated May 14, 2026 · Updated 21 times

Summary

This study tested a combination of chest radiation and the immunotherapy drug durvalumab in 51 elderly or frail patients with stage III lung cancer who could not tolerate chemotherapy. The goal was to see if this approach is safe and can shrink tumors. Results focused on side effects like lung inflammation and tumor response at 3 months.

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Contacts and locations

Locations

  • DRK Kliniken Berlin-Mitte

    Berlin, 13359, Germany

  • Gemeinschaftspraxis für Hämatologie und Onkologie

    Münster, 48153, Germany

  • Kliniken Maria Hilf GmbH

    Mönchengladbach, 41063, Germany

  • Kliniken der Stadt Köln gGmbH, Lungenklinik Merheim

    Cologne, 51109, Germany

  • Klinikum Ludwigsburg

    Ludwigsburg, 71640, Germany

  • Lungenklinik Hemer, Pneumologie und Thorakale Onkologie

    Hemer, 58675, Germany

  • Onkodok GmbH

    Gütersloh, 33332, Germany

  • Pi.Tri-Studien GmbH

    Offenburg, 77654, Germany

  • Sana Klinikum Offenbach GmbH

    Offenbach, 63069, Germany

  • Thoraxklinik am Universitätsklinikum Heidelberg

    Heidelberg, 69126, Germany

  • Universitätsklinikum Aachen

    Aachen, 52074, Germany

  • Universitätsmedizin Göttingen

    Göttingen, 37075, Germany

  • Universitätsmedizin Mainz

    Mainz, 55131, Germany

  • Vincentius-Diakonissen-Kliniken gAG

    Karlsruhe, 76137, Germany

Conditions

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