Can a cream boost Radiofrequency's Anti-Aging power?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female, aged 30-60 years; 2. Fine lines on both sides of the forehead meet Grade 1-5 according to the Skin Aging Atlas; 3. Crow's feet on both sides meet Grade 2-5 according to the Skin Aging Atlas; 4. Perioral wrinkles on both sides meet Grade 1-7 or nasolabial folds on both sides meet Grade 1-6 according to the Skin Aging Atlas; 5. Lower facial laxity and sagging meet Grade 1-5 according to the Skin Aging Atlas; 6. Subjects with consistent skin condition on both sides of the face who are scheduled to receive unipolar radiofrequency treatment; 7. Able to comply well with the study requirements and maintain a regular lifestyle throughout the study period; 8. Able to read and understand all contents of the informed consent form and voluntarily sign the ICF; 9. Agree not to use any cosmetics, medications, or health supplements that may affect the study results during the trial period. Exclusion Criteria: 1. Allergic constitution or history of severe allergies (e.g., immediate hypersensitivity symptoms, allergic dermatitis); 2. Presence of facial skin diseases (including severe freckles, atopic dermatitis, psoriasis, acute eczema, severe acne, etc.), skin infections (including viral, bacterial, fungal), or skin masses of unknown nature; 3. Presence of large areas of birthmarks, scratch marks, vitiligo, pigmented nevi, keloids, or other skin manifestations on the face that may affect the evaluation; 4. Presence of implantable electronic devices in the body (e.g., pacemaker, implantable cardioverter-defibrillator); 5. Diagnosed with serious clinical conditions such as endocrine diseases, immune system diseases, severe organ failure, or malignant tumors; 6. Diagnosed with severe mental illness or cognitive dysfunction, deemed by the investigator as unable to complete the evaluation or questionnaires involved in the study; 7. Received or planned to receive facial radiofrequency or botulinum toxin treatment within 6 months prior to enrollment or during the study; 8. Received chemotherapy or systemic corticosteroids within 3 months prior to enrollment; 9. Received or planned to receive facial photoelectric treatments (e.g., laser, intense pulsed light), fillers (e.g., sodium hyaluronate, collagen), thread lifts, or other aesthetic procedures within 3 months prior to enrollment or during the study; 10. Received or planned to receive facial mesotherapy or chemical peeling within 1 month prior to enrollment or during the study; 11. Used cosmetics, skincare products, or topical medications with firming or anti-wrinkle claims (e.g., glycolic acid, salicylic acid, mandelic acid, tretinoin, hydroquinone, azelaic acid, adapalene, etc.) on the face within 14 days prior to enrollment; 12. Other conditions that, in the investigator's judgment, render the subject unsuitable for unipolar radiofrequency treatment; 13. Pregnant or breastfeeding women; 14. Participated in other interventional clinical trials within 1 month prior to enrollment; 15. Other circumstances under which the investigator considers the subject should not participate in this clinical trial.