New drug R289 offers hope for blood disorder patients who failed other therapies

NCT ID NCT05308264

Recruiting now Disease control Sponsor: Rigel Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tests an experimental drug called R289 in about 86 adults with a type of blood cancer called lower-risk myelodysplastic syndromes (MDS). Participants must have tried other standard treatments without success. The main goal is to check the drug's safety and side effects, and also to see if it can reduce or eliminate the need for red blood cell transfusions. The study is currently recruiting.

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Conditions

The condition(s) this trial relates to.

myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW RISK MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27705, United States
Ichan School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Intermountain Healthcare
RECRUITING

Salt Lake City, Utah, 84009, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mount Sinai Medical Center
WITHDRAWN

Miami Beach, Florida, 33140, United States
Oncology Clinical Research Referral Office
RECRUITING

Hackensack, New Jersey, 07601, United States
Rutgers Cancer Institute of New Jersey
WITHDRAWN

New Brunswick, New Jersey, 09083, United States
Stanford Cancer Institute
RECRUITING

Palo Alto, California, 94304, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
University of California, Irvine
RECRUITING

Orange, California, 92868, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Texas, Southwestern
RECRUITING

Dallas, Texas, 75390, United States
WashU Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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