New drug cocktail aims to shrink Hard-to-Treat breast tumors before surgery

NCT ID NCT07189884

First seen Nov 01, 2025 · Last updated May 06, 2026 · Updated 24 times

Summary

This early-stage study tests whether adding two targeted drugs (pyrotinib and darcilib) to standard hormone therapy can shrink tumors before surgery in people with HR-positive, HER2-low breast cancer. The trial plans to enroll 33 patients with locally advanced disease. The main goal is to see how many patients have their tumor disappear or shrink significantly after treatment.

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