New lung cancer drug pumitamig takes on standard therapy in major trial

NCT ID NCT07361510

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial compares a new drug called pumitamig to the standard drug pembrolizumab as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called PD-L1 (at least 50%). The study will enroll 750 participants and measure how long they live without their cancer growing and overall survival. The goal is to see if pumitamig can work better than the current standard.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pumitamig (BMS-986545)

What this could lead to

If pumitamig works better than pembrolizumab, it could become a new first-line option for people with advanced lung cancer and high PD-L1 levels, potentially improving survival.

What could go wrong

This is an early-phase 3 trial, so results are not yet known. Pumitamig may not be more effective than pembrolizumab and could have unexpected side effects. The study only includes people with very high PD-L1, so findings may not apply to all lung cancer patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER (NSCLC)

Contacts and locations

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AOU di Ferrara Arcispedale S. Anna
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Ferrara (Cona), Emilia-Romagna, 44124, Italy

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Addenbrooke's Hospital
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Cambridge, CB2 2QQ, United Kingdom

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Izmir, 35110, Turkey (Türkiye)

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Local Institution - 0365
NOT_YET_RECRUITING

Aberdeen, Aberdeenshire, AB25 2ZN, United Kingdom

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Local Institution - 0367
NOT_YET_RECRUITING

Istanbul, 34899, Turkey (Türkiye)

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Local Institution - 0374
NOT_YET_RECRUITING

Córdoba, X5000BAL, Argentina

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Local Institution - 0375
NOT_YET_RECRUITING

São Paulo, São Paulo, 01509-010, Brazil

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Local Institution - 0376
NOT_YET_RECRUITING

Galveston, Texas, 77555, United States

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Local Institution - 0381
NOT_YET_RECRUITING

San Antonio, Texas, 78260, United States

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Local Institution - 0383
NOT_YET_RECRUITING

Cincinnati, Ohio, 45220, United States

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Local Institution - 0384
NOT_YET_RECRUITING

Spokane, Washington, 99218, United States

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Local Institution - 0385
NOT_YET_RECRUITING

Mexico City, 14210, Mexico

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Local Institution - 0386
NOT_YET_RECRUITING

Monterrey, Nuevo León, 64623, Mexico

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Local Institution - 0387
NOT_YET_RECRUITING

Kaohsiung City, 82445, Taiwan

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Local Institution - 0397
NOT_YET_RECRUITING

Dijon, 21079, France

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Local Institution - 0398
NOT_YET_RECRUITING

Nice, Alpes-Maritimes, 06189, France

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Local Institution - 0399
NOT_YET_RECRUITING

Lausanne, 1011, Switzerland

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Local Institution - 0403
NOT_YET_RECRUITING

Oakland, California, 94611, United States

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Local Institution - 0405
NOT_YET_RECRUITING

Chiang Mai, 50200, Thailand

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Local Institution - 0407
NOT_YET_RECRUITING

Anaheim, California, 92801, United States

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Local Institution - 0411
NOT_YET_RECRUITING

Prince George, British Columbia, V2M7E9, Canada

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Local Institution - 0412
NOT_YET_RECRUITING

Augusta, Georgia, 30912, United States

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Local Institution - 0414
NOT_YET_RECRUITING

Oshawa, Ontario, L1G2B9, Canada

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Local Institution - 0415
NOT_YET_RECRUITING

Ankara, 06800, Turkey (Türkiye)

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Local Institution - 0416
NOT_YET_RECRUITING

Walnut Creek, California, 94598, United States

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Local Institution - 0417
NOT_YET_RECRUITING

Sapporo, Hokkaido, 060-0063, Japan

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Local Institution - 0418
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73109, United States

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Local Institution - 0420
NOT_YET_RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina

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Local Institution - 0421
NOT_YET_RECRUITING

Marshfield, Wisconsin, 54449, United States

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Local Institution - 0422
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States

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Local Institution - 0423
NOT_YET_RECRUITING

Urbana, Illinois, 61801, United States

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Local Institution - 0426
NOT_YET_RECRUITING

Norwich, East, NR47UY, United Kingdom

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Local Institution - 0427
NOT_YET_RECRUITING

Goraj, Gujarat, 391760, India

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Local Institution - 0428
NOT_YET_RECRUITING

Dortmund, North Rhine-Westphalia, 44263, Germany

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Local Institution - 0432
NOT_YET_RECRUITING

Cologne, North Rhine-Westphalia, 51109, Germany

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Lyell McEwin Hospital
RECRUITING

Elizabeth Vale, South Australia, 5112, Australia

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Meander Medisch Centrum
RECRUITING

Amersfoort, 3813 TZ, Netherlands

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Missouri Cancer Associates
RECRUITING

Columbia, Missouri, 65201, United States

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Mohtaseb Cancer Center & Blood Disorders
RECRUITING

Bullhead City, Arizona, 86442, United States

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Northwest Cancer Centers, P.C.
RECRUITING

Dyer, Indiana, 46311, United States

Contact Phone: •••-•••-••••
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
RECRUITING

Marietta, Georgia, 30060, United States

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OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
RECRUITING

Barakaldo, Basque Country, 48903, Spain

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Oncohelp Medical Center
RECRUITING

Timișoara, Timiș County, 300239, Romania

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Orange Coast Memorial Medical Center
RECRUITING

Fountain Valley, California, 92708, United States

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Palo Verde Hematology Oncology
RECRUITING

Glendale, Arizona, 85304, United States

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Pusan National University Yangsan Hospital
RECRUITING

Busan, Kyǒngsangnam-do, 50612, South Korea

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Royal Marsden Hospital (Chelsea)
RECRUITING

London, SW3 6JJ, United Kingdom

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Royal Wolverhampton Nhs Trust
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom

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Saiseikai Kumamoto Hospital
RECRUITING

Kumamoto, 861-4193, Japan

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Sanatorio Plaza
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina

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Sendai Kousei Hospital
RECRUITING

Sendai, Miyagi, 9810914, Japan

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Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China

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Shanghai East Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200120, China

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Shenandoah Oncology, P.C.
RECRUITING

Winchester, Virginia, 22601, United States

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Shonan Kamakura General Hospital
RECRUITING

Kamakura, Kanagawa, 247-8533, Japan

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Southern Cancer Center Pc
RECRUITING

Daphne, Alabama, 36526, United States

Contact Phone: •••-•••-••••
Taichung Veterans General Hospital
RECRUITING

Taichung, 407, Taiwan

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Tampereen yliopistollinen sairaala
RECRUITING

Tampere, 33521, Finland

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Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78217, United States

Contact Phone: •••-•••-••••
The Royal Marsden NHS Foundation Trust
RECRUITING

Sutton, South East, SM25PT, United Kingdom

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Toyohashi Municipal Hospital
RECRUITING

Toyohashi, Aichi-ken, 441-8570, Japan

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University Cancer & Blood Center, LLC
RECRUITING

Athens, Georgia, 30607, United States

Contact Phone: •••-•••-••••
Vaasan Keskussairaala
RECRUITING

Vaasa, 65130, Finland

Contact Phone: •••-•••-••••
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom

Contact Phone: •••-•••-••••
WellSpan Oncology Research
RECRUITING

York, Pennsylvania, 17403, United States

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Østfold Hopsital, Kalnes
RECRUITING

Grålum, Akershus, 1714, Norway

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