Can a single nerve injection quiet chronic pelvic pain?
NCT ID NCT07828574
First seen Sep 18, 2026 · Last updated Sep 18, 2026
Summary
Researchers are testing whether an ultrasound-guided injection of the local anesthetic articaine plus the steroid triamcinolone near the pudendal nerve reduces pain in adults with pudendal neuralgia, a chronic perineal pain condition. The trial enrolls 120 people whose pain has lasted more than three months and has not improved enough with standard medications or physical therapy. Participants are randomly assigned to receive either the active injection or a saline placebo, and neither they nor the clinicians know which one they get. The main question is whether more people report at least 50% less pain four weeks after the active injection compared with placebo, with follow-up on quality of life, sleep, physical function, pain medication use, and side effects over 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A single ultrasound-guided injection of the local anesthetic articaine plus the steroid triamcinolone near the pudendal nerve
- What this could lead to
- If it works, this could offer a targeted injection option for people whose chronic perineal pain has not responded to standard medications or physical therapy.
- What could go wrong
- The trial is small and single-center, so results may not hold up in larger or more varied groups. Nerve blocks can cause temporary numbness, soreness, or bleeding, and some people may get little relief.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
120 people
The number who actually took part.
- Started
-
Jan 2025
- Expected to finish
-
Nov 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Clinical Nantes criteria for pudendal neuralgia (all 4 mandatory criteria) * Pain intensity on the Numeric Rating Scale (NRS) greater than 4 out of 10 during the previous 7 days * Pain duration exceeding 3 months * Failure of prior conservative therapy (pregabalin ≥150 mg/day, or gabapentin ≥900 mg/day, or physical therapy) for more than 8 weeks * Age 18 years or older Exclusion Criteria: * Pudendal nerve compression by a space-occupying lesion (tumor, cyst, endometriosis) on pelvic MRI * Coagulopathy (INR \>1.4, platelets \<50×10\^9/L) * Use of anticoagulants or antiplatelet agents that cannot be discontinued 5-7 days before the block (per cardiology consultation) * Active infection at the intended injection site, or systemic infection/sepsis * Allergy to amide-type local anesthetics or corticosteroids * Pregnancy or lactation * Psychiatric conditions precluding understanding of the procedure or completion of questionnaires
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Pudendal neuralgia pudendal nerve entrapment chronic pelvic pain are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kharlampiev Clinic
Irkutsk, Irkutsk Regio, 664003, Russia