New gel could treat painful skin vein bumps
NCT ID NCT06653842
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a gel containing sirolimus (PTX-022) on 15 people with visible venous malformations on the skin. The goal is to see if the gel is safe and can improve the appearance and symptoms of these abnormal veins. Participants apply the gel daily for 12 weeks, and doctors track changes and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sirolimus topical gel 3.9%
- What this could lead to
- If it works, this could offer a non-invasive topical treatment option for visible venous malformations on the skin.
- What could go wrong
- This is a small, early-phase trial with only 15 participants and no control group, so results may not be conclusive. Side effects from sirolimus gel are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital of Orange County
Irvine, California, 92612, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Colorado Children's Hospital
Aurora, Colorado, 80045, United States
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Johns Hopkins
Baltimore, Maryland, 21287, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Minnesota Clinical Study Center
New Brighton, Minnesota, 55112, United States
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Stanford University
Palo Alto, California, 94305, United States
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University of North Carolina
Chapel Hill, North Carolina, 27516, United States
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University of Utah Health
Salt Lake City, Utah, 84113, United States