New pill could clear psoriasis skin in major trial

NCT ID NCT06842199

Recruiting now Disease control Sponsor: Beijing InnoCare Pharma Tech Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests an oral drug called ICP-488 in 383 adults with moderate to severe plaque psoriasis. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug can significantly clear or nearly clear the skin, as measured by doctor assessments and symptom scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ICP-488 (an oral tablet)
What this could lead to: If successful, this could provide a new oral treatment option for people with moderate to severe plaque psoriasis, potentially improving skin clearance.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is only tested in Chinese adults, so results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLAQUE PSORIASIS PATIENTS

Contacts and locations

Locations

Affiliated Hospital of Chengde Medical University
COMPLETED

Chengde, Hebei, 067000, China
Beijing Chao-Yang Hospital，Capital Medical University
COMPLETED

Beijing, Beijing Municipality, 100020, China
Beijing Friendship Hospital, Capital Medical University
COMPLETED

Beijing, Beijing Municipality, 100050, China
Beijing Tongren Hospital,CMU
COMPLETED

Beijing, Beijing Municipality, 100730, China
Chengdu Second People's Hospital
COMPLETED

Chengdu, Sichuan, 610017, China
Chongqing Traditional Chinese Medicine Hospital
COMPLETED

Chongqing, Chongqing Municipality, 400021, China
Dermatology Hospital of Jiangxi Province
COMPLETED

Nanchang, Jiangxi, 330000, China
Dermatology Hospital of Southern Medical University
COMPLETED

Guangzhou, Guangdong, 510091, China
First Affiliated Hospital of Gannan Medical University
COMPLETED

Ganzhou, Jiangxi, 341000, China
Fujian Medical University Union Hospital
COMPLETED

Fuzhou, Fujian, 350001, China
Henan Provincial People's Hospital
COMPLETED

Zhengzhou, Henan, 450003, China
Hospital for skin diseases,Institute of dermatology chinese academy of medical sciences，peking union medical college
COMPLETED

Nanjing, Jiangsu, 210042, China
Huashan Hospital, Fudan University
COMPLETED

Shanghai, Shanghai Municipality, 200040, China
Jingzhou Central Hospital
COMPLETED

Jingzhou, Hubei, 434020, China
Liuzhou People's Hospital
COMPLETED

Liuzhou, Guangxi, 545006, China
Nanyang Central Hospital
COMPLETED

Nanyang, Henan, 473000, China
Northeast International Hospital
COMPLETED

Shenyang, Liaoning, 110000, China
Peking University Third Hospital
COMPLETED

Beijing, Beijing Municipality, 100191, China
Qilu Hospital of Shandong University
COMPLETED

Jinan, Shandong, 250012, China
Sanmenxia Central Hospital
COMPLETED

Sanmenxia, Henan, 472000, China
Shanghai Skin Disease Hospital skin Disease of tongji University
COMPLETED

Shanghai, Shanghai Municipality, 200443, China
Sichuan Provincial People's Hospital
COMPLETED

Chengdu, Sichuan, 610072, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
COMPLETED

Guangzhou, Guangdong, 510120, China
Taiyuan Central Hospital
COMPLETED

Taiyuan, Shanxi, 030009, China
The 2nd Affiliated Hospital of Harbin Medical University
COMPLETED

Harbin, Heilongjiang, 150001, China
The Affiliated Hospital of Guizhou Medical University
COMPLETED

Guiyang, Guizhou, 550001, China
The First Affiliated Hospital Of Ningbo University
RECRUITING

Ningbo, Zhejiang, 315000, China
The First Affiliated Hospital of Anhui Medical University
COMPLETED

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Chongqing Medical University
COMPLETED

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Fujian Medical University
COMPLETED

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Kunming Medical University
COMPLETED

Kunming, Yunnan, 650032, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi’an, Shanxi, 710061, China
The First Hospital of Jilin University
COMPLETED

Changchun, Jilin, 130021, China
The First People's Hospital of Changzhou
COMPLETED

Changzhou, Jiangsu, 213003, China
The First People's Hospital of Lianyungang
COMPLETED

Lianyungang, Jiangsu, 222002, China
The Fourth Affiliated Hospital, Zhejiang University School of Medicine
COMPLETED

Jinhua, Zhejiang, 322000, China
The Second Affiliated Hospital Zhejiang University School of Medicine
COMPLETED

Hangzhou, Zhejiang, 310009, China
The Second Affiliated Hospital of Henan University of Science and technology
COMPLETED

Luoyang, Henan, 471000, China
The Second Affiliated Hospital of Wannan Medical College
COMPLETED

Wuhu, Anhui, 241000, China
The Second Affiliated Hospital of Xi'an Jiaotong University
COMPLETED

Xi’an, Shanxi, 710114, China
The Second Hospital of Hebei Medical University
COMPLETED

Shijiazhuang, Hebei, 050000, China
The Second Xiangya Hospital of Central South
COMPLETED

Changsha, Hunan, 410011, China
The first Affiliated hospital of Wenzhou Medical University
COMPLETED

Wenzhou, Zhejiang, 325000, China
Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
COMPLETED

Tianjin, Tianjin Municipality, 300120, China
Wuhan Hospital Of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital)
COMPLETED

Wuhan, Hubei, 430022, China
Xiangya Hospital of Central South University
COMPLETED

Changsha, Hunan, 410008, China