New pill shows promise for clearing psoriasis in early trial

NCT ID NCT05357755

First seen May 14, 2026 · Last updated May 14, 2026

Summary

This study tested an experimental oral tablet, JNJ-77242113, in 90 adults with moderate-to-severe plaque psoriasis. Participants took the tablet or a placebo for 16 weeks. The main goal was to see if the drug could reduce psoriasis severity by at least 75% compared to placebo. This is an early-phase trial, so more research is needed to confirm safety and effectiveness.

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Contacts and locations

Locations

  • ActivMed Practices and Research

    Beverly, Massachusetts, 01915, United States

  • ActivMed Practices and Research

    Portsmouth, New Hampshire, 03801, United States

  • Arlington Center for Dermatology

    Arlington, Texas, 76011, United States

  • CHRU Brest - Hopital Morvan

    Brest, 29200, France

  • CHU de Grenoble Hopital Albert Michallon

    La Tronche, 38700, France

  • CHU de Nice Hopital de l Archet

    Nice, 06200, France

  • Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna

    Lodz, 90-338, Poland

  • DermEdge Research

    Mississauga, Ontario, L4Y 4C5, Canada

  • Dermatology Research Institute Inc

    Calgary, Alberta, T2J 7E1, Canada

  • Dermatology Specialists

    Louisville, Kentucky, 40241, United States

  • Epiphany Dermatology of Kansas, LLC

    Overland Park, Kansas, 66210, United States

  • Hautarztpraxis

    Bramsche, 49565, Germany

  • Health Concepts

    Rapid City, South Dakota, 57702, United States

  • Hosp. Univ. San Cecilio

    Granada, 18016, Spain

  • Hosp. Univ. de Cruces

    Barakaldo, 48902, Spain

  • Hosp. Virgen Macarena

    Seville, 41009, Spain

  • Lawrence J Green MD LLC

    Rockville, Maryland, 20850, United States

  • Lynderm Research Inc.

    Markham, Ontario, L3P 1X2, Canada

  • Northshore University Healthsystem

    Skokie, Illinois, 60077, United States

  • Polyclinique de Courlancy

    Reims, 51100, France

  • Privatpraxis Dr. Hilton & Partner

    Düsseldorf, 40212, Germany

  • Specderm Poznanska sp j

    Bialystok, 15 375, Poland

  • Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna

    Krakow, 30 002, Poland

  • Stoll Dermatology

    Beverly Hills, California, 90212, United States

  • The Guenther Dermatology Research Centre

    London, Ontario, N6A 3H7, Canada

  • The Pennsylvania Centre for Dermatology, LLC

    Exton, Pennsylvania, 19341, United States

  • Toronto Research Centre

    Toronto, Ontario, M3H 5Y8, Canada

  • Unity Clinical Research

    Oklahoma City, Oklahoma, 73118, United States

  • Universitaetsmedizin Rostock

    Rostock, 18057, Germany

  • Universitatsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • Universitatsklinikum Frankfurt

    Frankfurt am Main, 60590, Germany

  • Universitatsklinikum Munster

    Münster, 48149, Germany

  • Universitatsklinikum Schleswig Holstein Campus Lubeck

    Lübeck, 23538, Germany

  • Windsor Dermatology, PC

    East Windsor, New Jersey, 08520, United States

Conditions

Explore the condition pages connected to this study.