Can a second anesthetic drug cut inhaled gas use during heart valve surgery?
NCT ID NCT07798089
First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time
Summary
This trial tests whether adding dexmedetomidine to propofol anesthesia reduces the amount of isoflurane, an inhaled anesthetic, needed during minimally invasive heart valve surgery. Researchers will compare two groups of about 30 patients each: one receiving propofol plus dexmedetomidine, and the other receiving propofol plus a placebo. The study tracks total isoflurane consumption, perioperative outcomes, and how quickly patients recover after surgery. Participants are adults under 60 with mild systemic disease who are scheduled for this type of valve surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A combination of propofol and dexmedetomidine, given as continuous infusions during anesthesia, compared with propofol plus a placebo infusion.
- What this could lead to
- If it works, this could point toward a safer, more efficient anesthesia method for heart valve surgery, with less inhaled anesthetic and faster early recovery.
- What could go wrong
- This is an early-phase trial with only 60 patients, so results may not apply broadly. Adding dexmedetomidine can lower blood pressure or heart rate, which needs careful monitoring during surgery.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. patients belonging to American Society of Anesthesiologists (ASA) class I or II 2. patients scheduled for minimally invasive cardiac valve surgery. Exclusion Criteria: 1. patient more than 60 years 2. patients having neurological/psychological disorders, 3. patient having severe systemic disorders (renal/hepatic dysfunction and severe respiratory disorder), 4. patient with history of allergy to the study drugs, 5. patient with left ventricular ejection fraction \< 40%,
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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