Can a Two-Step injection take the sting out of anesthesia?
NCT ID NCT07763548
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This trial tests whether giving propofol—a common anesthesia drug—in two smaller doses instead of one large bolus can reduce the pain patients feel at the injection site. About 2,000 adults undergoing non-cardiac surgery will receive either a single injection or a split dose, and their recalled pain will be compared. The goal is to find a simple way to make anesthesia induction more comfortable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- propofol
- What this could lead to
- If effective, this simple two-step injection method could reduce the common pain patients feel when receiving propofol, improving comfort during anesthesia induction.
- What could go wrong
- The trial is a single-center study, and the benefit may be modest or not consistently reproducible. Pain perception is subjective, and results may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.