Can probiotics calm a crying baby? new study investigates
NCT ID NCT05271747
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two different probiotic supplements in 112 healthy infants diagnosed with colic to see if they could reduce daily crying and fussing. Babies received either a multi-strain probiotic or a single-strain probiotic for 21 days. The researchers also tracked feeding type, regurgitation, bowel movements, and parent anxiety to understand what influences colic symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Probiotic multi-strain formulation (Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330) and probiotic single-strain formulation (Lactobacillus reuteri DSM17938)
What this could lead to
If successful, this could point toward a probiotic option to reduce crying and fussing in babies with colic, potentially easing stress for parents.
What could go wrong
This is a small, completed study with 112 infants, so results may not apply to all babies. Probiotics may not work for every case of colic, and individual responses can vary.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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HM Hospitals
Barcelona, Spain
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Hm Hospitals
Madrid, Spain
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Hospital Medica Sur, room 108, tower 2
Mexico City, 14050, Mexico
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University Hospital Santa Lucía
Cartagena, Murcia, 30202, Spain