Can probiotics boost gut health in Tube-Fed seniors?

NCT ID NCT07437352

Completed Disease control Sponsor: Istituto Nazionale di Ricovero e Cura per Anziani Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a 30-day course of a probiotic supplement could improve the balance of gut bacteria and increase production of beneficial short-chain fatty acids in frail elderly patients who receive all their nutrition through a feeding tube at home. Twenty-seven participants were randomly assigned to receive either the probiotic or a placebo. Researchers also monitored for digestive issues like constipation and diarrhea.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: probiotic supplement (Lactobacillus rhamnosus and Lactobacillus paracasei)
What this could lead to: If it works, this could point toward a simple way to improve gut health and reduce digestive problems in frail elderly people who rely on tube feeding.
What could go wrong: This is a very small, early-stage study with only 27 participants. The results may not apply to all elderly patients, and the benefits may be modest or not statistically significant.

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Conditions

The condition(s) this trial relates to.

Frailty

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENTERAL NUTRITION

Contacts and locations

Locations

IRCCS INRCA Hospital

Ancona, 60127, Italy

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