Could a probiotic and laser ease menopause symptoms?
NCT ID NCT06978907
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a daily probiotic (Lactobacillus crispatus M247) combined with vaginal laser therapy can improve vaginal health and reduce symptoms like dryness, itching, and pain in menopausal women with atrophic vulvovaginitis. 75 women were split into two groups: one received laser alone, the other laser plus the probiotic. Researchers measured symptom changes and vaginal bacteria over three months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lactobacillus crispatus M247 (Crispact®) probiotic
- What this could lead to
- If it works, this combination could offer a non-hormonal option to ease vaginal discomfort in menopausal women.
- What could go wrong
- This is a small, early study with only 75 participants. The probiotic may not significantly improve symptoms beyond laser alone, and individual results may vary.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital State of Republic of San Marino
San Mariano, 47893, Italy
-
Villa Margherita Clinic
Roma, 00161, Italy
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