Can a probiotic pill stop antibiotic tummy troubles? new study tests best dose
NCT ID NCT07380009
First seen Jun 26, 2026 · Last updated Jul 16, 2026 · Updated 3 times
Summary
This study looks at how well people can stick to taking a probiotic supplement while on antibiotics, and whether it helps prevent diarrhea. Forty adults who have had diarrhea with antibiotics before will take either one or two sachets of the probiotic daily. Researchers will track adherence, side effects, and bowel changes to find the most practical dosing plan.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- multistrain probiotic Vivomixx® 460 Neo 9
- What this could lead to
- If successful, this could show the best way to take probiotics with antibiotics to prevent diarrhea and improve comfort.
- What could go wrong
- This is a small, early-stage study with only 40 people, so results may not apply to everyone. It focuses on adherence, not on proving the probiotic works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
40 people
The number who actually took part.
- Started
-
Dec 2025
- Finished
-
May 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and women aged over 18 years * Initiation of oral antibiotic therapy lasting more than 3 days * History of diarrhea during previous antibiotic treatment * Eligible antibiotics include: (a) amoxicillin with clavulanic acid, (b) clindamycin, and (c) second- or third-generation cephalosporins * Willingness to provide informed consent to participate in the study Exclusion Criteria: * Pregnancy or breastfeeding * Age under 18 years * Diagnosis of a chronic autoimmune disease (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriasis) * Diagnosis of type I or type II diabetes * Renal or hepatic disease * Current use of immunosuppressive medications * Current use of other supplements, probiotics, prebiotics, or synbiotics * Use of antibiotics within the past month * Use of laxatives or antidiarrheal medications within the past 2 weeks * Pre-existing diarrhea within the past 2 weeks * Self-reported allergy to any component of the probiotic * Psychological conditions affecting the ability to provide informed consent (e.g., dementia, psychosis, substance use) * Gastrointestinal surgery within the past 6 months
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Antibiotic therapy are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
School of Physical Education, Sport Science and Dietetics
Trikala, 42132, Greece
More trials for these conditions
Other studies related to the condition(s) this trial covers.