A simple pill may supercharge antibiotics against stubborn bone infections
NCT ID NCT07764302
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This trial tests whether adding probenecid—a drug that slows antibiotic removal from the body—to standard amoxicillin treatment can raise antibiotic levels in the blood of adults with bone or joint infections. The goal is to see if this combination helps more patients reach the antibiotic concentration needed to kill the bacteria effectively. Fifty-seven participants will receive probenecid for a short period while their amoxicillin levels are measured, comparing results with and without the added drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- probenecid added to amoxicillin
- What this could lead to
- If probenecid boosts amoxicillin levels enough, it could help more people overcome stubborn bone and joint infections without needing higher antibiotic doses.
- What could go wrong
- This is a small, early-stage proof-of-concept study, so results may not apply broadly. Probenecid can cause side effects like kidney issues or allergic reactions, and the added benefit may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Ambroise-Paré, AP-HP
Paris, 92100, France
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Hôpital André Mignot, Centre Hospitalier de Versailles
Chesnay, 78150, France
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Hôpital Beaujon AP-HP
Clichy, 92110, France
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Hôpital Bretonneau, CHU Tours
Tours, 37000, France
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Hôpital Cochin Port Royal, AP-HP
Paris, 75 014, France
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Hôpital Henri-Mondor, AP-HP
Créteil, 94010, France
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Hôpital Lariboisière-Fernand Widal, AP-HP
Paris, 75010, France
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Hôpital Saint-Antoine - AP-HP
Paris, 75012, France