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New drug aims to unclog Alzheimer's brain, trial underway

NCT ID NCT06182085

Ongoing Disease control Sponsor: PRInnovation GmbH Source: ClinicalTrials.gov ↗

First seen Jan 07, 2026 · Last updated May 02, 2026 · Updated 15 times

Summary

This study tests a new drug called PRI-002 in 304 people with early Alzheimer's (mild cognitive impairment or mild dementia). The drug is designed to break apart small sticky protein clumps in the brain that are thought to cause memory and thinking problems. The goal is to see if PRI-002 is safe and can slow down the disease. Participants will receive either the drug or a placebo for 48 weeks.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A-Shine, s.r.o.

    Pilsen, 30100, Czechia

  • AOU Policlinico Umberto I

    Rome, 00161, Italy

  • ASST Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Brain Research Center Amsterdam B.V.

    Amsterdam, 1081 GN, Netherlands

  • Brain Research Center Den Bosch B.V.

    's-Hertogenbosch, 5223 LA, Netherlands

  • Brain Research Center Zwolle B.V.

    Zwolle, 8025 AZ, Netherlands

  • CLINTRIAL, s.r.o.

    Prague, 10000, Czechia

  • Charité - Universitätsmedizin

    Berlin, 13125, Germany

  • Clinica Neurologica Dipartimento di Neuroscienze e Imaging (CAST)

    Chieti, 66013, Italy

  • Euromedis Sp. z o.o., Centrum Medyczne EUROMEDIS

    Szczecin, 70-111, Poland

  • FORBELI s.r.o.

    Prague, 14800, Czechia

  • Fondazione IRCCS.Istituto Neurologico Carlo Besta

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario A. Gemelli IRCCS

    Rome, 00168, Italy

  • Fundació ACE - Institut Català de Neurociències Aplicades

    Barcelona, 08028, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120, Spain

  • Hospital Universitario Doctor Peset

    Valencia, 46017, Spain

  • Hospital Universitario Virgen Macarena,

    Seville, 41003, Spain

  • Hospital Viamed Montecanal

    Zaragoza, 50012, Spain

  • INEP Medical s.r.o.

    Prague, 18600, Czechia

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • ISPG - Institut für Studien zur Psychischen Gesundheit

    Mannheim, 68165, Germany

  • Krakowska Akademia Neurologii Sp. z o.o., Centrum Neurologii Klinicznej

    Krakow, 30-505, Poland

  • Neuro Health Centrum ltd.

    Brno, 62800, Czechia

  • NeuroCor, ul. Medweciego 7/U12

    Krakow, 31-870, Poland

  • Neuroprotect Sp. z o.o., Centrum Medyczne NeuroProtect

    Warsaw, 01-684, Poland

  • Neuropsychiatrie s.r.o.

    Prague, 16000, Czechia

  • NeuropsychiatrieHK, s.r.o.

    Hradec Králové, 50341, Czechia

  • Ospedale Bellaria - IRCCS Istituto delle Scienze Neurologiche

    Bologna, 40139, Italy

  • Ospedale Santa Maria della Misericordia

    Perugia, 06129, Italy

  • Revit Sp. z o.o., Podlaskie Centrum Psychogeriatrii

    Bialystok, 15-756, Poland

  • Technische Universität München

    München, 81675, Germany

  • Uniklinik RWTH Aachen

    Aachen, 52074, Germany

  • University Medical Center Rostock

    Rostock, 18147, Germany

  • Universitätsklinikum Düsseldorf

    Düsseldorf, 40225, Germany

  • Universitätsklinikum Magdeburg

    Magdeburg, 39120, Germany

  • Universitätsklinikum Münster - Klinik für Allgemeine Neurologie

    Münster, 48149, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Wielospecjalistyczne Centrum Medyczne "Ibismed" s.c.

    Zabrze, 41-800, Poland

Conditions

Explore the condition pages connected to this study.

ALZHEIMER'S DISEASE, EARLY ONSET MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE