New hope for NF2: experimental drug aims to shrink tumors and save hearing

NCT ID NCT07131722

First seen Jan 26, 2026 · Last updated May 12, 2026 · Updated 11 times

Summary

This early-stage trial tests a daily drug called PRG-N-01 in 25 adults with neurofibromatosis type II (NF2), a genetic condition that causes non-cancerous tumors on nerves, often leading to hearing loss. The study aims to find the safest and most effective dose, and to see if the drug can shrink tumors and improve quality of life, including hearing. Participants will take the drug for 96 weeks and have regular clinic visits for monitoring.

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