New pill combo could take the ouch out of root canals
NCT ID NCT06298383
First seen Nov 19, 2025 · Last updated Apr 30, 2026 · Updated 19 times
Summary
This study tested whether taking a combination of trypsin, bromelain, and rutoside before a root canal helps the numbing shot work better and lowers pain afterward. 124 adults with painful tooth inflammation (pulpitis) took the medication or a placebo before treatment. Researchers measured pain levels during the procedure and for a week after. The goal is to find a safer alternative to standard painkillers or steroids for dental pain.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Faculty of Dentistry, Cairo University
Cairo, 4450113, Egypt
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Faculty of Oral and Dental Medicine, Egyptian Russian University
Cairo, Cairo Governorate, 11829, Egypt
Conditions
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