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Could a common steroid improve success after vasectomy reversal?

NCT ID NCT04788823

Disease control Sponsor: Charitable Union for the Research and Education of Peyronie's Disease Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests whether taking prednisone, a steroid, after vasectomy reversal surgery can improve sperm quality and increase the chance of pregnancy. Men aged 18-65 with a partner under 36 and no known fertility issues are eligible. Participants receive different doses of prednisone, and researchers compare sperm counts and pregnancy rates to see if the drug helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
prednisone
What this could lead to
If effective, prednisone could become a simple, low-cost addition to vasectomy reversal surgery, potentially improving sperm quality and the chances of pregnancy.
What could go wrong
This is a small, early-stage trial, and results may not apply to all men. Prednisone has side effects like weight gain, mood changes, and increased infection risk, which could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

75 people

The number who actually took part.

Started

Feb 2021

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men undergoing a first-time vasectomy reversal at the Male Fertility and Peyronie's Clinic * 18-65 years of age * Current sexual partner with desire to achieve pregnancy immediately * Intent of reversal to restore fertility * Partner \<36 years of age * Partner with no known fertility issues * Prior history of paternity Exclusion Criteria: * Current corticosteroid use * Prior vasectomy reversal * Prior chemotherapy * Testosterone use within 1 year of the vasectomy reversal * Solitary testicle * History of diabetes mellitus * History of systemic fungal infection * Hypertension * Any degree of diagnosed renal insufficiency * Partner on birth control within past 3 months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vasectomy reversal

Contacts and locations

Locations

  • Cure PD

    Orem, Utah, 84057, United States