New breathing test may prevent ICU setbacks
NCT ID NCT07634783
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a quick, non-invasive breathing measurement (Delta Pocc) can predict which ICU patients will need a breathing tube reinserted after it is removed. Researchers will measure airway pressure during a standard breathing trial in 120 adults. If the test works, it could help doctors make safer decisions about removing breathing support.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could give doctors a simple, non-invasive tool to better predict which ICU patients are ready to breathe on their own, reducing the risk of extubation failure.
- What could go wrong
- This is a small, early observational study at a single center, so results may not apply to all patients. The measurement is experimental and will not change current care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult intensive care unit patients receiving invasive mechanical ventilation for at least 24 hours who are considered clinically ready for a spontaneous breathing trial as part of routine weaning assessment.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 years or older * Invasive mechanical ventilation for at least 24 hours * Clinical indication for spontaneous breathing trial according to the treating clinical team * Hemodynamic and clinical stability * Technical feasibility for respiratory physiological measurements, including expiratory occlusion maneuver Exclusion Criteria: * Significant hemodynamic instability * Severe uncontrolled hypoxemia * Major cardiac arrhythmias * Agitation or patient-ventilator asynchrony preventing reliable measurements * Significant air leak interfering with respiratory measurements * Technical inability to perform expiratory occlusion maneuver * Limitation of life-sustaining treatment * Incomplete primary outcome follow-up
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Sanatorio Parque
Rosario, Santa Fe Province, 2000, Argentina